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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 128))

Abstract

There exists a rather extensive literature on possible interrelations between calcium and phosphate metabolism on the one hand and lipid metabolism on the other hand. Unfortunately, much of the information is dated or contradictory and few of the interrelationships have been clarified with respect to the underlying mechanism. For the purpose of this discussion, table 1 provides a conceptual framework of how various aspects of Ca and phosphate homeostasis may act on different reactions in lipid metabolism.

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References

  1. J.N. Morris, M.D. Crawford, J.A. Heady, Hardness of local water supplies and mortality from cardiovascular disease in county boroughs of England and Wales Lancet i, 860 (1961)

    Article  Google Scholar 

  2. T.W. Anderson, W.H. Le Riche, J.S. Mac Kay, Sudden death and ischemic heart disease - correlations with hardness of local water supply, New Engl.J.Med.28o: 8o5 (1969)

    Google Scholar 

  3. A.G. Shaper, D.G. Clayton, J.N. Morris, Hard and soft water in relation to the incidence of cardiovascular disease, in: “Atherosclerosis III”, G. Schettler, A. Weizel, eds., Springer, Berlin (1974) p 715

    Google Scholar 

  4. V. Linden, Vitamin D and myocardial infarction, Brit. Med.J. 3: 647 (1974)

    Article  PubMed  CAS  Google Scholar 

  5. V. Torstein, T. Kenneth, D.S. Thelle, O.H. Forde, Troms. Heart Study: Vitamin D metabolism and myocardial interaction, Brit.Med.J. 2: 176 (1979)

    Google Scholar 

  6. S. Werner, K. Hall, H. Low, Similar effects of calcitonin, insulin and somatomedin on lipolysis and uptake of calcium and glucose in rat adipose tissue in vitro, Horm.Metab.Res. 6: 319 (1974)

    Article  PubMed  CAS  Google Scholar 

  7. S. Akgun, D. Rudman, Relationship between mobilisation of free fatty acids from adipose tissue, and the concentrations of calcium in the extracellular fluid and in the tissue, Endocrinology 84: 926 (1969)

    Article  PubMed  CAS  Google Scholar 

  8. S. Werner, H. Low, Adenylate cyclase activity in rat adipocyte plasma membranes after adrenalectomy and administration of cortisone acetate - effects of calcium ions and hormonal stimulation, Horm.Metab. Res. 6: 365 (1974)

    Article  PubMed  CAS  Google Scholar 

  9. R.J. Schimmel, The influence of extracellular calcium ion on hormone activated lipolysis, Biochim.Biophys. Acta 326: 272 (1973)

    Article  PubMed  CAS  Google Scholar 

  10. A. Bensandoun, C. Ehnholm, D. Steinberg, W.V. Brown, Purification and characterisation of lipoprotein lipase from pig adipose tissue, J.Biol.Chem. 249: 222o (1974)

    Google Scholar 

  11. H. Yacowitz, H.I. Fleischman, M.L. Bierenbaum, Effect of oral calcium upon serum lipids in man, Brit.Med. J. 1: 1352 (1965)

    Article  PubMed  CAS  Google Scholar 

  12. A.I. Fleischman, H. Yacowitz, T. Hayton, M.L. Bierenbaum, Effects of dietary calcium upon lipid metabolism in mature male rats fed beef tallow, J.Nutr. 38: 255 (1966)

    Google Scholar 

  13. A.I. Fleischman, H. Yacowitz, T. Hayton, M.L. Bierenbaum, Long-term studies on the hypolipemic effect of dietary calcium in mature male rats fed cocoa butter, J.Nutr. 91: 151 (1967)

    PubMed  CAS  Google Scholar 

  14. M.L. Bierenbaum, A.I. Fleischman, R.I. Raichelson, Long-term human studies on the lipid effects of oral calcium, Lipids 7:2o2 (1972)

    Article  Google Scholar 

  15. E. Maibach, Die Beeinflussung des Gesamtcholesterins der beta-Lipoproteide und Gesamtlipide des Serums durch orale und parenterale Calciumzufuhr, Schweiz. Med.Wschr. 97: 418 (1967)

    Google Scholar 

  16. E. Pfleiderer, Tierexperimentelle Untersuchungen überArteriosklerose unter besonderer Berücksichtigung der Kranzarteriensklerose, Virchows Arch.Path.Anat. 284: 154 (1932)

    Google Scholar 

  17. C.D. De Langen, W.F. Donath, Vitamin D,sclerosis of the arteries and the danger of feeding extra vitamin D to older people with a view on the development of different forms of arteriosclerosis, Acta Med.Scand. 156: 317 (1956)

    Article  Google Scholar 

  18. Lee Cheng-Chun, R.G. Herrmann, Effects of vitamin D sucrose, corn oil and endocrines on tissue cholesterol in rats, Circulation Res. 7: 354 (1959)

    Article  Google Scholar 

  19. J.O. Forfar, S.L. Tompsett, W. Forshall, Biochemical studies in idiopathic hypercalcemia of infancy, Arch.Dis.Childh. 34: 525 (1959)

    Article  PubMed  CAS  Google Scholar 

  20. A.I. Fleischman, M.L. Bierenbaum, R. Raichelson, T. Hayton, P. Watson, Vitamin D and hypercholesterolemia in adult humans, in: “Atherosclerosis” (Proc. 2nd Intern.Symp.), R.J. Jones, ed., Springer, Berlin (197o) p 468

    Google Scholar 

  21. M.Dempsey, Discussion, in: “Atherosclerosis” (Proc. 2nd Intern.Symp.), R.J. Jones, ed., Springer, Berlin (197o) p 485

    Google Scholar 

  22. S. Werner, H. Low, Stimulation of lipolysis and calcium accumulation by parathyroid hormone in rat adipose tissue in vitro after adrenalectomy and administration of high doses of cortisone acetate, Horm.Metab.Res. 5: 292 (1973)

    Article  PubMed  CAS  Google Scholar 

  23. L. Gozariu, K. Forster, J.D. Faulhaber, H. Minne, R. Ziegler, Parathyroid hormone and calcitonin: Influences upon lipolysis of human adipose tissue, Horm.Metab.Res. 6: 243 (1974)

    Article  PubMed  CAS  Google Scholar 

  24. T.K. Sinha, P. Thajchayapong, S.F. Queener, D.O. Allen, N.H. Bell, On the lipolytic action of parathyroid hormone in man, Metabolism 25: 251 (1976)

    Article  PubMed  CAS  Google Scholar 

  25. H. Kather, B. Simon, Adenylate cyclase of human fat cell ghosts, stimulation of enzyme activity by pa-rathyroid hormone, J.Clin.Invest. 59: 73o (1977)

    Google Scholar 

  26. H. Kather, B. Simon, Human fat cell adenylate cyclase:Responsiveness towards catecholamines, peptide hormones and prostaglandins, in: “Lipoprotein Metabolism and Endocrine Regulation”, L.W. Hessel, H.M.J. Kraus, eds., Elsevier, Amsterdam (1979) p 189

    Google Scholar 

  27. D. Hallberg, S. Werner, Circulatory and lipolytic effects of parathyroid hormone, Horm.Metab.Res. 9: 424 (1977)

    Article  PubMed  CAS  Google Scholar 

  28. M.A. Moxley, N.H. Bell, R.S. Wagle, D.O. Allen,J. Ashmore, Parathyroid hormone stimulation of glu-cose and urea production in isolated liver cells, Am.J.Physiol. 227:lo58 (1974)

    Google Scholar 

  29. C.C. Heuck, E. Ritz, Does parathyroid hormone play a role in lipid metabolism?, Contrib.Nephrol, (in press)

    Google Scholar 

  30. H.R. Harter, J.V. Santiago, W.E. Rutherford, E. Slatopolsky, S. Klahr, The relative roles of calcium, phosphorous and parathyroid hormone in glucose and tolbutamide mediated insulin release, J.Clin.Invest. 58: 359 (1976)

    Article  PubMed  CAS  Google Scholar 

  31. E. Paloyan, J. Kolar, J. Castles, D. Paloyan, V. Harper, The role of parathyroid hormone in lipid metabolism, Fed.Proc. 22: 676 (1963)

    Google Scholar 

  32. S. Ljunghall, H. Lithell, L. Wide, Hyperlipoproteinemia type IV and hyperinsulinemia in primary hyper-parathyroidism. Effect of parathyroidectomy, Acta Endoer. (Kopenhagen) (in press)

    Google Scholar 

  33. P. De Moor, G. Creyttens, R. Bouillon, J.V. Joossens, Results obtained in 75 patients operated upon for hyperparathyroidism: low cholesterol levels in overt primary hyperparathyroidism, Ann.Endocr. 34: 616 (1973)

    PubMed  Google Scholar 

  34. T. Christenson, K. Einarson, Serum lipids before and after parathyroidectomy in patients with primary hyperparathyroidism, Clin.Chim.Acta 78: 411 (1977)

    Article  Google Scholar 

  35. M. Cantin, Kidney, parathyroid and lipemia, Lab. Invest. 14: 1691 (1965)

    PubMed  CAS  Google Scholar 

  36. S.G. Massry, Is parathyroid hormone an uremic toxin? Nephron 19: 125 (1977)

    Article  PubMed  CAS  Google Scholar 

  37. C.C. Heuck, W. Kreusser, O. Mehls, E. Ritz, Die Rolle von PTH bei der urämischen Hyperlipämie, Verh.Dtsch. Ges.Inn.Med. 85 (1979) (in press)

    Google Scholar 

  38. H. Kather, H.C. Heuck, W. Tschöpe, E. Ritz, B. Simon, Unchanged hormone sensitivity of rat fat cell adenylate cyclase in uremia, Clin.Nephrol. 8: 324 (1977)

    PubMed  CAS  Google Scholar 

  39. J.D. Bagdade, E. Yee, D.E. Wilson, E. Shafrir, Hyperlipidemia in renal failure: Studies of plasma lipo-proteins, hepatic triglyceride production and tissue lipoprotein lipase in a chronical uremic rat model, J.Lab.Clin.Med. 91: 176 (1978)

    PubMed  CAS  Google Scholar 

  40. C.C. Heuck, M. Liersch, E. Ritz, K. Stegmeier, A. Wirth, O. Mehls, Hyperlipoproteinemia in experimental chronic renal insufficiency in the rat, Kidney International 14: 142 (1978)

    Article  PubMed  CAS  Google Scholar 

  41. M.L. Sanfelippo, R.S. Swenson, G.M. Reaven, Reduction of plasma triglycerides by diet in subjects with chronic real failure, Kidney International 11: 54 (1977)

    Article  PubMed  CAS  Google Scholar 

  42. J.D. Brunzell, A.P. Goldberg, Hormonal regulation of human adipose tissue lipoprotein lipase, in: “Atherosclerosis IV”, G. Schettler Springer, Berlin (1977) p 336

    Google Scholar 

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© 1980 Plenum Press, New York

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Ritz, E., Heuck, CC., Boland, R. (1980). Phosphate, Calcium and Lipid Metabolism. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_25

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  • DOI: https://doi.org/10.1007/978-1-4615-9167-2_25

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