Abstract
Both because of its properties as a buffer and its function as a major intracellular anion, phosphate plays a pivotal role in the maintenance of acid-base homeostasis. This review is concerned with the impact of phosphate on three interrelated aspects of acid-base physiology and pathophysiology. These are the role of phosphate as a urinary buffer, its relationship to the formation of urinary carbon dioxide tension, and the effects of phosphate depletion on urinary acidification.
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References
Arruda JAL and Kurtzman NA: Metabolic acidosis and alkalosis. Clin Nephrol 7: 201–215, 1977.
Massry SG and Coburn JW: Divalent ions and the kidney. In Pathophysiology of the Kidney (Kurtzman NA and Martinez- Maldonado M, eds); Charles C. Thomas, Springfield, 1977.
Arruda JAL, Nascimento L, Kumar SK and Kurtzman NA: Factors influencing the formation of urinary carbon dioxide tension. Kidney Internat 11: 307–317, 1977.
Arruda JAL, Nascimento L, Mehta PK, Rademacher DR, Sehy JT, Westenfelder C and Kurtzman NA: The critical importance of urinary concentrating ability in the generation of urinary carbon dioxide tension. J Clin Invest 60: 922–935, 1977.
Kurtzman NA and Arruda JA: Physiologic significance of urinary carbon dioxide tension. Min Elect Metab 1: 241–246, 1978.
Massry SG: Effect of phosphate depletion on renal function and metabolism. Proc Vllth Internat Cong Neph 7: 625–633, 1978.
Gold SW, Massry SG, Arieff AI and Coburn JW: Renal bicarbonate wasting during phosphate depletion. A possible cause of altered acid-base homeostasis in hyperparathyroidism. J Clin Invest 52: 2556–2565, 1973.
Emmett M. Goldfarb S, Agus ZS and Narins RC: The pathophysiology of acid-base changes in chronically phosphate depleted rats. Bone-Kidney interactions. J Clin Invest 59: 291–298, 1977.
Kurtz TW and Hsu CH: Impaired distal nephron acidification in chronically phosphate depleted rats. Pflüg Arch 337: 229–234, 1978.
Julka NK, Sabatini S, Arruda JAL and Kurtzman NA: Distal acidification defect (AD) induced by phosphate depletion. Clin Res 26: 691A, 1978.
Kohaut EC, Klish WJ, Beachler CW and Hill LL: Reduced renal acid excretion in malnutrition: A result of phosphate depletion. Amer J Clin Nutr 30: 861–867, 1977.
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© 1980 Plenum Press, New York
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Kurtzman, N.A., Arruda, J.A.L. (1980). Phosphate and Acid-Base Homeostasis. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_24
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_24
Publisher Name: Springer, Boston, MA
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