Abstract
The mechanism for the phosphaturia of respiratory acidosis is not well understood because there are concomitant alterations in arterial blood pCO2, pH, bicarbonate and phosphate which could all affect urinary phosphate excretion1–6. Recently, Webb et al1 demonstrated in the rat that alterations in the blood levels of phosphate, bicarbonate and parathyroid hormone could not entirely account for the phosphaturia of respiratory acidosis and concluded that it was the result of a direct effect of the elevated blood pCO2 on renal phosphate transport. Our present clearance and micropuncture experiments were, therefore, designed to reexamine the relationship between blood pCO2 and the phosphaturia of respiratory acidosis.
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References
R. K. Webb, P. B. Woodhall, C. C. Tisher, G. Glaubiger, F. A. Neelon, and R. R. Robinson, Relationship between phosphaturia and acute hypercapnia in the rat, J. Clin. Invest. 60: 829 (1977).
M. Fulop and P. Brazeau, The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs, J. Clin. Invest. 47: 983 (1968).
N. Bank, H. S. Aynedjian, and S. W. Weinstein, A microperfusion study of phosphate reabsorption by the rat proximal renal tubule, J. Clin. Invest. 54: 1040 (1974).
K. Baumann, G. Rumrich, F. Papavassiliou, and S. Kloss, Letters and notes: pH dependence of phosphate reabsorption in the proximal tubule of rat kidney. Pflugers Arch. 360: 183 (1975).
J. B. Puschett and M. Goldberg, The relationship between the renal handling of phosphate and bicarbonate in man, J. Lab. Clin. Med. 73: 956 (1969).
A. Mercado, E. Slatopolsky, and S. Klahr, On the mechanisms responsible for the phosphaturia of bicarbonate administration, J. Clin. Invest. 56: 1386 (1975).
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© 1980 Plenum Press, New York
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Wen, SF. (1980). Indirect Effect of Hypercapnia on the Phosphaturia of Respiratory Acidosis. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_14
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_14
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