Abstract
Substantial contributions to our knowledge of purine metabolism and the origin and elimination of uric acid, have been made from studies in man and animals. Studies early in the century1 established that the body could be sustained on a diet free of purine (endogenous metabolism) and the role of dietary (exogenous) purine in the aetiology of the gouty attack. The effect of protein in increasing the urinary excretion (clearance) of dietary derived uric acid, and the opposing effect of starvation, on endogenous uric acid clearance was also demonstrated1. Recent studies have confirmed these findings and indicate that age onset classical gout is predominantly a disease of plenty2,3.
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References
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© 1980 Plenum Press, New York
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Potter, C.F., Cadenhead, A., Simmonds, H.A., Cameron, J.S. (1980). Differential Absorption of Purine Nucleotides, Nucleosides and Bases. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man-III. Advances in Experimental Medicine and Biology, vol 122A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9140-5_32
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DOI: https://doi.org/10.1007/978-1-4615-9140-5_32
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