Abstract
Weber1 found elevated glucose-6-phosphate dehydrogenase activities in serum of patients suffering from psoriasis. In psoriatic skin lesions this enzyme activity was also enhanced (Weber2). Herdenstam3 reported that a great part of glucose is metabolized via the pentose phosphate cycle. Ribose-5-phosphate is the source for 5-phosphoribosyl-1-pyrophosphate (PRPP) which is of great importance for the purine salvage pathway. In this paper the incorporation of adenine, guanine and hypoxanthine via the salvage pathway into intact erythrocytes of psoriatic patients was studied in contrast to healthy people.
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References
G. Weber, Über das Vorkommen der Glucose-6-Phosphat-Dehydrogena-se im Blutserum von Psoriasis vulgaris-Kranken, Arch. klin. exp. Derm. 215:603 (1963).
G. Weber and G. W. Korting, Glucose-6-Phosphate Dehydrogenase in Human Skin, J. invest. Derm. 42:167 (1964).
C. G. Herdenstam, On the in vitro metabolism of labelled glucose in normal and psoriatic skin slices, Acta derm.-venerol. 42:47 (1962).
O. H. Lowry, N. J. Rosenbrough, A. L. Farr and R. J. Randall, Protein measurement with the Folin phenol reagent, J. biol. Chem. 193:265 (1951).
A. Hershko, A. Razin, T. Shoshani and J. Mager, Turnover of Purine Nucleotides in Rabbit Erythrocytes. II. Studies in vitro, Biochim. Biophys. Acta 149:59 (1967).
B. M. Dean, H. A. Simmonds and A. Cadenhead, A Comparative study of Purine Metabolism by Human and Pig Erythrocytes in vitro, Biochem. Pharm. 22:3189 (1973).
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© 1980 Plenum Press, New York
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Partsch, G., Mayer, F., Eberl, R., Luger, A. (1980). Salvage Pathway in Erythrocytes of Patients with Psoriasis. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man-III. Advances in Experimental Medicine and Biology, vol 122A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9140-5_27
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DOI: https://doi.org/10.1007/978-1-4615-9140-5_27
Publisher Name: Springer, Boston, MA
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