Abstract
Recently, a number of clinical and pharmacological observations have provided evidence for two reabsorptive sites for urate within the nephron, one proximal to and one distal to the secretory locus.1–6 Our own data conform to a four-component system for the renal handling of urate, involving complete filtration of uric acid at the glomerulus, reabsorption of 99.3% of the filtered load, secretion further distal in the nephron, and reabsorption of the majority of secreted urate.7 This reference should be consulted for details of the studies on renal tubular secretion of urate.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.S. Bennett, J. Bond, I. Singer, and A.J. Gottlieb, Hypouricemia in Hodgkin’s disease, Ann. Intern. Med. 76:751 (1972).
D.M. Wilson, and N.P. Goldstein, Renal urate excretion in patients with Wilson’s disease. Kidney Internat. 4:331 (1973).
T.H. Steele, and G. Boner, Origins of uricosuric response, J. Clin. Invest. 52:1368 (1973).
H.S. Diamond, and J.S. Paolino, Evidence for a post-secretory reabsorptive site for uric acid in man, J. Clin. Invest. 52: 1491 (1973).
G. Lemieux, P. Vinay, and A. Gougoux, Nature of the uricosuric action of benziodarone. Am. J. Physiol. 224:1440 (1973).
L.B. Sorensen, and D.J. Levinson, Evidence for four components in the renal handling of uric acid in man, in: “Amino Acid Transport and Uric Acid Transport,” S. Silbernagl, F. Lang and R. Greger, eds., George Thieme, Stuttgart (1976).
D.J. Levinson, and L.B. Sorensen, Renal handling of uric acid in man. Evidence for a four component system, Ann, Rheum. Dis, in press.
E. Praetorius, and J.E. Kirk, Hypouricemia: with evidence for tubular elimination of uric acid, J. Lab. Clin. Med. 35:865 (1950)
A.B. Gutman, T.F. Yü, and L. Berger, Tubular secretion of urate in man, J. Clin. Invst. 38:1778 (1959).
A.B. Gutman, and T.F. Yü, A three-component system for regulation of renal excretion of uric acid in man. Trans. Assoc. Amer. Physns. 74:353 (1961)
L.B. Sorensen, and D.J. Levinson, Isolated defect in post-secretory reabsorption of uric acid, Ann. Rheum. Dis, in press.
R. Podevin, F. Paillard, and C. Amiel, Action de la benz-bromarone sur l’excrétion rénale de l’acide urique, Rev. Franc. d’Etudes Clin. Biol. 12:361 (1967).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Sorensen, L.B., Levinson, D.J. (1980). Determination of Tubular Secretion of Urate in Healthy and Gouty Men. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man-III. Advances in Experimental Medicine and Biology, vol 122A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9140-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9140-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9142-9
Online ISBN: 978-1-4615-9140-5
eBook Packages: Springer Book Archive