Skip to main content
SpringerLink
Log in

Metabolic Changes Accompanying Phagocytosis

  • Chapter
Biochemistry and Metabolism

Abstract

A vast knowledge of the biochemical properties of phagocytic cells at rest and during phagocytosis has been gained in the past twenty years. During this period, several excellent reviews have been written on selected aspects of this broad field. The review by Karnovsky (1962) is recommended to those who are interested in the historical development of the biochemical studies on phagocytic cells. Among the more recent reviews, those written by the following authors can be mentioned: Cline (1970), for a survey of the various metabolic pathways of leucocytes, including a chapter on nucleic acid and protein metabolism; Sbarra et al (1977), for the oxidative changes in phagocytizing polymorphonuclear leukocytes and their relationship to microbicidal activity; Elsbach (1977), for a detailed analysis of the lipid metabolism; Klebanoff (1975), and Babior (1978) for the biochemical basis of the microbicidal mechanisms of polymorphonuclear leukocytes; Karnovsky et al. (1975) and Rossi et al. (1975) for the metabolism of resting and phagocytizing mononuclear phagocytes. A treatment of the phagocytic engulfment as a surface phenomenon is found in the book edited by Van Oss et al. (1975). Finally, a coverage of the various features of the phagocytic process is found in a book by Klebanoff and Clark (1978) and, less extensively, in a recent review by De Chatelet (1979).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aellig, A., Maillard, M., Phavorin, A., and Frei, J., 1977, The energy metabolism of the leukocyte.DC. Changes in the concentrations of the coenzymes NAD, NADH, NADP, NADPH in polymorphonuclear leucocytes during phagocytosis of Staphylococcus aureus and due to the action of phospholipase C, Enzyme 22:207.

    PubMed  CAS  Google Scholar 

  • Allen, R. C., Stjernholm, R. C., Steele, R. H., 1972, Evidence for the generation of an electron excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity, Biochem. Biophys. Res. Commun. 47:677.

    Google Scholar 

  • Andreae, W. A., 1955, A sensitive method for the estimation of hydrogen peroxide in biological material, Nature (London) 175:859.

    Article  CAS  Google Scholar 

  • Auclair, C., Torres, M., Hakim, J., and Troube, H., 1978, NADPH-oxidation activities in subcellular fractions isolated from resting or phagocytosing human polymorphonuclears, Am. J. Hematol. 4:113.

    Article  PubMed  CAS  Google Scholar 

  • Babior, B. M., 1977a, Recent studies on oxygen metabolism in human neutrophils: Superoxide and chemiluminescence, in: Superoxide and Superoxide Dismutases (A. M. Michelson, J. M. McCord, and I. Fridovich, eds.), pp. 271–282, Academic Press, London.

    Google Scholar 

  • Babior, B. M., 1977b, The superoxide forming enzyme responsible for the respiratory burst of neutrophils, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 235–242, Piccin Medical Books, Padova.

    Google Scholar 

  • Babior, B. M., 1978, Oxygen-dependent microbial killing by phagocytes, N. Engl. J. Med. 298:659.

    Article  PubMed  CAS  Google Scholar 

  • Babior, B. M., Kipnes, R. S., and Curnutte, J. T., 1973, Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent, J. Clin. Invest. 52:741.

    Article  PubMed  CAS  Google Scholar 

  • Babior, B. M., Curnutte, J. T., and Kipnes, R. S., 1975, Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes, J. Clin. Invest. 56:1035.

    Article  PubMed  CAS  Google Scholar 

  • Babior, B. M., Curnutte, J. T., and McMurrich, B. J., 1976, The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst, J. Clin. Invest. 58:989.

    Article  PubMed  CAS  Google Scholar 

  • Badwey, J. A., and Karnovsky, M. L., 1979, Production of superoxide anion hydrogen peroxide by an NADH-oxidase in guinea pig polymorphonuclear leukocytes, J. Biol. Chem. 254:11530.

    PubMed  CAS  Google Scholar 

  • Baehner, R. L., 1975, Subcellular distribution of nitroblue tetrazolium reductase (NBT-R) in human polymorphonuclear leukocytes (PMN), J. Lab. Clin. Med. 86:785.

    PubMed  CAS  Google Scholar 

  • Baehner, R. L., and Johnston, R. B., 1972, Monocyte function in children with neutropenia and chronic infection, Blood 40:31.

    PubMed  CAS  Google Scholar 

  • Baehner, R. L., Gilman, N., and Karnovsky, M. L., 1970, Respiration and glucose oxydation in human and guinea pig leucocytes: Comparative studies, J. Clin. Invest. 49:692.

    Article  PubMed  CAS  Google Scholar 

  • Baehner, R. L., Johnston, R. B., and Nathan, G.D., 1972, Comparative study of the metabolic and bactericidal characteristics of severely glucose 6-phosphate dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with granulomatous disease, J. Reticuloen-dothel. Soc. 12:150.

    PubMed  CAS  Google Scholar 

  • Baldridge, C. W., Gerard, R. W., 1933, The extrarespiration of phagocytosis, Am. J. Physiol. 103:235.

    CAS  Google Scholar 

  • Basford, R. E., Bartus, B., Kaplan, S. S., and Platt, D., 1977, Glutathione peroxidase and phagocytosis, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 265–275, Piccin Medical Books, Padua.

    Google Scholar 

  • Bass, D. A., De Chatelet, L. R., Burk, R. F., Shirley, P., and Szejda, P., 1977, Polymorphonuclear leukocyte bactericidal activity and oxidative metabolism during glutathione peroxidase deficiency, Infect. Immun. 18:78.

    PubMed  CAS  Google Scholar 

  • Beck, W. S., 1958, Occurrence and control of the phosphogluconate oxidation pathway in normal and leukemic leukocytes, J. Biol. Chem. 232:271.

    PubMed  CAS  Google Scholar 

  • Beckman, G., Lundgren, E., and Tärnvick, A., 1973, Superoxide dismutase isoenzymes in different human tissues. Their genetic control and intracellular localization, Hum. Hered. 23:338.

    Article  PubMed  CAS  Google Scholar 

  • Bellavite, P., Dri, P., Bisiacchi, B., and Patriarca, P., 1977, Catalase deficiency in myeloperoxidase deficient polymorphonuclear leucocytes from chicken, FEBS Letters 81:73.

    Article  PubMed  CAS  Google Scholar 

  • Bellavite, P., Dri, P., Berton, G., and Zabucchi, G., 1980a. Un nuovo test di funzionalità fagocitaria basato sulla misura della produzione di superossido anione (O2 -). I. Principi generali di esecuzione, LAB 7:67.

    CAS  Google Scholar 

  • Bellavite, P., Berton, G., and Dri, P., 1980b, Studies on the NADPH oxidation by subcellular particles from phagocytosing polymorphonuclear leukocytes. Evidence for the involvement of three mechanisms, Biochim. Biophys. Acta (in press).

    Google Scholar 

  • Berlin, R. D., and Fera, J. P., 1977, Changes in membrane microviscosity associated with phagocytosis: Effects of colchicine, Proc. Natl. Acad. Sci. USA 74:1072.

    Article  PubMed  CAS  Google Scholar 

  • Berton, G., Bellavite, P., Dri, P., Cramer, R., 1981, Subcellular localization of NADPH oxidase in resting and stimulated guinea pig neutrophils (submitted for publication).

    Google Scholar 

  • Borregaard, N., Johansen, K. S., Tahdorff, E., and Wandall, J. H., 1979, Cytochrome b is present in neutrophils from patient with chronic granulomatous disease, Lancet 1:949.

    Article  PubMed  CAS  Google Scholar 

  • Briggs, R. T., Drath, D. B., Karnovsky, M. L., and Karnovsky, M. J., 1975, Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method, J. Cell Biol. 67:566.

    Article  PubMed  CAS  Google Scholar 

  • Briggs, R. T., Karnovsky, M. L., and Karnovsky, M. J., 1977, Hydrogen peroxide production in chronic granulomatous disease. A cytochemical study of reduced pyridine nucleotide oxidases, J. Clin. Invest. 59:1088.

    Article  PubMed  CAS  Google Scholar 

  • Brune, K., and Spitznagel, J. K., 1973, Peroxidaseless chicken leukocytes: Isolation and characterization of antibacterial granules, J. Infect. Dis. 127:84.

    Article  PubMed  CAS  Google Scholar 

  • Cagan, R. H., and Karnovsky, M. L., 1964, Enzymatic basis of the respiratory stimulation during phagocytosis, Nature (London) 204:255.

    Article  CAS  Google Scholar 

  • Chau, R. M., and Karnovsky, M. J., 1977, Lipid-protein lateral separation in the plasma membrane of phagocytosing macrophages, J. Cell Biol. 75:238a.

    Google Scholar 

  • Cline, M. J., 1970, Leukocyte metabolism, in: Regulation of Hematopoiesis (A. S. Gordon, ed.), Vol. 2, pp. 1045–1079, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Cohen, H. J., Chovaniec, M. E., and Davies, W., 1978, Subcellular localization and kinetics of activation of the granulocyte superoxide generating system, Fed. Proc. 37:1276.

    Google Scholar 

  • Cooper, M. R., De Chatelet, L. R., McCall, C. E., LaVia, M. F., Spurr, C. L., and Baehner, L. R., 1972, Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity, J. Clin. Invest. 51:769.

    Article  PubMed  CAS  Google Scholar 

  • Curnutte, J. T., and Babior, B. M., 1974, Biological defense mechanisms: The effect of bacteria and serum on superoxide production by granulocytes, J. Clin. Invest. 53:1562.

    Article  Google Scholar 

  • Curnutte, J. T., Kipnes, R. S., and Babior, B. M., 1975, Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from granulocytes of patient with chronic granulomatous disease, N. Engl. J. Med. 293:628.

    Article  PubMed  CAS  Google Scholar 

  • Curnutte, J. T., Karnovsky, M. L., and Babior, B. M., 1976, Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement J. Clin. Invest. 57:1059.

    Article  PubMed  CAS  Google Scholar 

  • De Chatelet, L. R., 1979, Phagocytosis by human neutrophils, in: Phagocytes and Cellular Immunity (H. Gadebusch, ed.), pp. 1–55, CRC Press, West Palm Beach, Florida.

    Google Scholar 

  • De Chatelet, L. R., McCall, C. E., McPhail, L. C., and Johnston, R. B., Jr., 1974, Superoxide dismutase activity in leukocytes, J. Clin. Invest. 53:1197.

    Google Scholar 

  • De Chatelet, L. R., McPhail, L. C., Mullikin, D., and McCall, C. E., 1975a, An isotopic assay for NADPH oxidase activity and some characteristics of the enzyme from human polymorphonuclear leukocytes, J. Clin. Invest. 55:714.

    Article  Google Scholar 

  • De Chatelet, L. R., Mullikin, D., and McCall, C. E., 1975b, Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes, J. Lab. Clin. Med. 85:245.

    Google Scholar 

  • De Chatelet, L. R., Shirley, P. S., McPhail, L. C., Huntler, C. C., Muss, H. B., and Bass, D. A., 1977, Oxidative metabolism of eosinophil, Blood 50:525.

    Google Scholar 

  • Dewald, B., Baggiolini, M., Curnutte, J. T., and Babior, B. M., 1979, Subcellular localization of the superoxide-forming enzyme in human neutrophils, J. Clin. Invest. 63:21.

    Article  PubMed  CAS  Google Scholar 

  • Dri, P., Bisiacchi, B., Cramer, R., Bellavite, P., de Nicola, G., and Patriarca, P., 1978, Oxidative metabolism of chicken polymorphonuclear leucocytes during phagocytosis, Mol. Cell. Biochem. 22:159.

    Article  PubMed  CAS  Google Scholar 

  • Dri, P., Bellavite, P., Berton, G., and Rossi, F., 1979, Interrelationship between oxygen consumption, superoxide anion and hydrogen peroxide formation in phagocytosing guinea pig polymorphonuclear leukocytes, Mol. Cell. Biochem. 23:109.

    PubMed  CAS  Google Scholar 

  • Eggleston, L. V., and Krebs, H. A., 1974, Regulation of the pentose phosphate cycle, Biochem. J. 138:425.

    PubMed  CAS  Google Scholar 

  • Elsbach, P., 1977, White cells, in: Lipid Metabolism in Mammals (F. Snyder, ed.), Vol. 1, pp. 259–276, Plenum Press, New York.

    Chapter  Google Scholar 

  • Evans, A. E., and Kaplan, N. O., 1966, Pyridine nucleotide transhydrogenase in normal human and leukemic cells, J. Clin, Invest. 45:1268.

    Article  CAS  Google Scholar 

  • Evans, W. H., and Karnovsky, M. L., 1961, A possible mechanism for the stimulation of some metabolic functions during phagocytosis, J. Biol. Chem. 236:Pc30.

    PubMed  CAS  Google Scholar 

  • Evans, W. H., and Karnovsky, M. L., 1962, The biochemical basis of phagocytosis. IV. Some aspects of carbohydrate metabolism during phagocytosis, Biochemistry, 1:159.

    Article  PubMed  CAS  Google Scholar 

  • Gabig, T. G., and Babior, B. M., 1979, The O2-forming oxidase responsible for the respiratory burst in human neutrophils, J. Biol. Chem. 254:9070.

    PubMed  CAS  Google Scholar 

  • Gabig, T. G., Kipnes, R. S., and Babior, B. M., 1978, Solubilization of the O2 ‒-forming activity responsible for the respiratory burst in human neutrophils, J. Biol. Chem. 253:6663.

    PubMed  CAS  Google Scholar 

  • Gallin, J. I., Gallin, E. K., Malech, H. L., and Cramer, E. B., 1978, Structural and ionic events during leukocyte Chemotaxis, in: Leukocyte Chemotaxis: Methods, Physiology, and Clinical Implications Q. I. Gallin and P. G. Quie, eds.) pp. 123–141, Raven Press, New York.

    Google Scholar 

  • Gee, J. B. L., and Khandwala, A. S., 1976, Oxygen metabolism in the alveolar macrophage: Friend and foe? J. Reticubendothel. Soc. 19:229.

    CAS  Google Scholar 

  • Gee, J. B. L., Vassallo, C. L., Bell, P., Kaskin, J., Basford, R. E., and Field, J., 1970, Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis, J. Clin. Invest. 49:1280.

    Article  PubMed  CAS  Google Scholar 

  • Glock, G. E., and McLean, P., 1953, Further studies on the properties and assay of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver, Biochem. J. 55:400.

    PubMed  CAS  Google Scholar 

  • Goetzl, E. J., and Austen, K. F., 1974, Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors J. Clin. Invest. 53:591.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, B. D., Witz, G., Amoruso, M., and Troll, W., 1979, Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumption, Biochem. Biophys. Res. Commun. 88:854.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, I. M., Roos D., Kaplan, H. B., and Weissmann, G., 1975, Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis, J. Clin. Invest. 56:1155.

    Article  PubMed  CAS  Google Scholar 

  • Graham, R. C., Jr., Karnovsky, M. J., Shafer, A. W., Glass, E. A., and Karnovsky, M. L., 1967, Metabolic and morphological observations on the effect of surface active agents on leukocytes, J. Cell Biol. 32:629.

    Article  PubMed  CAS  Google Scholar 

  • Haber, F., and Weiss, J., 1934, The catalatyc decomposition of hydrogen peroxide by iron salts, Proc. R. Soc. London Set. A 147:332.

    Article  CAS  Google Scholar 

  • Hamers, M. N., Wever, R., van Shaik, M. L. J., Weening, R. S., and Roos, D., 1980, Cytochrome b and the superoxide-generating system in human neutrophils, in: The Significance of Superoxide and Superoxide Dismutase, Vol. 2, Biological and Clinical Aspects (W. H. Bannister and J. V. Bannister, eds.), Elsevier, New York.

    Google Scholar 

  • Hawkins, D., 1973, Neutrophilic leukocytes in immunologic reactions in vitro: Effect of cytochalasin B, J. Immunol 110:294.

    PubMed  CAS  Google Scholar 

  • Henson, P. M., and Oades, Z. G., 1973, Enhancement of immunologically induced granule exocytosis from neutrophils by cytochalasin B, J. Immunol. 110:290.

    PubMed  CAS  Google Scholar 

  • Higgins, C. P., Baehner, R. L., McCallister, J., and Boxer, L. A., 1978, Polymorphonuclear leukocyte species differences in the disposal of hydrogen peroxide (H2O2), Proc. Soc. Exp. Biol. Med. 158:478.

    PubMed  CAS  Google Scholar 

  • Hohn, D. C., and Lehrer, R. L, 1975, NADPH oxidase deficiency in X-linked chronic granulomatous disease, J. Clin. Invest. 55:707.

    Article  PubMed  CAS  Google Scholar 

  • Homan-Müller, J. W. T., Weening, R. S., and Roos, D., 1975, Production of hydrogen peroxide by phagocytizing human granulocytes, J. Lab. Clin. Med. 85:198.

    PubMed  Google Scholar 

  • Iverson, D., De Chatelet, L. R., Spitznagel, J. K., and Wang, P., 1977, Comparison of NADH and NADPH oxidase activities in granules isolated from human polymorphonuclear leukocytes with a fluorimetric assay, J. Clin. Invest. 59:282.

    Article  PubMed  CAS  Google Scholar 

  • Iverson, D. B., Wang-Iverson, P., Spitznagel, J. K., and De Chatelet, L. R., 1978, Subcellular localization of NAD(P)H oxidases in human neutrophilic polymorphonuclear leukocytes, Biochem. J. 176:175.

    PubMed  CAS  Google Scholar 

  • Iyer, G. Y. N., and Quastel, J. H., 1963, NADPH and NADH oxidation by guinea pig polymorphonuclear leukocytes, Can. J. Biochem. Physiol. 41:427.

    Article  PubMed  CAS  Google Scholar 

  • Iyer, G. Y. N., Islam, M. F., and Quastel, H. J., 1961, Biochemical aspects of phagocytosis, Nature (London) 192:535.

    Article  CAS  Google Scholar 

  • Johnston, R. B., Jr., Keele, B. B., Misra, H. P., Lehmeyer, J. E., Webb, L. S., Baehner, R. L., and Rajagopalan, K. V., 1975, The role of superoxide anion generation in phagocytic bactericidal activity: Studies with normal and granulomatous disease leukocytes, J. Clin. Invest. 55:1357.

    Article  PubMed  CAS  Google Scholar 

  • Johnston, R. B., Jr., Lehmeyer, J. E., and Guthrie, L. A., 1976, Generation of superoxide anion and chemiluminescence of human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G, J. Exp. Med. 143:1551.

    Article  PubMed  CAS  Google Scholar 

  • Kakinuma, K., 1974, Effects of fatty acids on the oxidative metabolism of leukocytes, Biochim. Biophys. Acta 348:76.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, S. S., Finch, S. C., and Basford, R. E., 1972, Polymorphonuclear leukocyte activation: Effects of phospholipase c, Proc. Soc. Exp. Biol. Med. 140:540.

    PubMed  CAS  Google Scholar 

  • Karnovsky, M. L., 1962, Metabolic basis of phagocytic activity, Physiol. Rev. 42:143.

    PubMed  CAS  Google Scholar 

  • Karnovsky, M. L., 1973, Chronic granulomatous disease-pieces of a cellular and molecular puzzle, Fed. Proc. 32:1527.

    PubMed  CAS  Google Scholar 

  • Karnovsky, M. L., Lazdins, J., and Simmons, S. R., 1975, Metabolism of activated mononuclear phagocytes at rest and during phagocytosis, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Fürth, ed.), pp. 423–439, Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Keston, A. S., and Brandt, R., 1965, The fluorimetric analysis of ultramicro quantities of hydrogine peroxide, Anal. Biochem. 11:1.

    Article  PubMed  CAS  Google Scholar 

  • Keusch, G. T., Douglas, S. D., Mildvan, D., and Hirschman, S. Z., 1972, 14C-Glucose oxidation in whole blood: A clinical assay for phagocytic disfunction, Infect. Immun. 5:414.

    PubMed  CAS  Google Scholar 

  • Kitagawa, S., Takaku, F., and Sakamoto, S., 1979, Possible involvement of proteases in superoxide production by human polymorphonuclear leukocytes, FEBS Letters 99:275.

    Article  PubMed  CAS  Google Scholar 

  • Klebanoff, S. J., 1975, Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes, Semin. Hematol. 12:117.

    PubMed  CAS  Google Scholar 

  • Klebanoff, S. J., and Clark, R. A., 1978, The Neutrophil: Function and Clinical Disorders, North Holland, Amsterdam.

    Google Scholar 

  • Klebanoff, S. J., and Hamon, C. B., 1972, Role of myeloperoxidase-mediated antimicrobicidal systems in intact leukocytes, J. Reticuloendothel. Soc. 12:170.

    PubMed  CAS  Google Scholar 

  • Klebanoff, S. J., and Hamon, C. B., 1975, Antimicrobial system of mononuclear phagocytes, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Fürth, ed.), pp. 507–531, Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Loor, F., Forni, L., and Pernis, B., 1972, The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins, Eur. J. Immunol. 2:203.

    Article  PubMed  CAS  Google Scholar 

  • Mandell, G. L., and Sullivan, G. W., 1971, Pyridine nucleotide oxidation by intact human polymorphonuclear neutrophils, Biochim. Biophys. Acta 234:43.

    Article  PubMed  CAS  Google Scholar 

  • McCord, J. M., and Day, E. D. J., 1978, Superoxide-dependent production of hydroxil radical catalyzed by iron-EDTA complex, FEBS Letters 80:130.

    Google Scholar 

  • McPhail, L. C., De Chatelet, R. L., Shirley, P. S., Wilfert, C., Johnston, R. B., Jr., and McCall, C. E., 1977, Deficiency of NADPH oxidase activity in chronic granulomatous disease, J. Pediatr. 90:213.

    Article  PubMed  CAS  Google Scholar 

  • Mendelson, D. S., Metz, E. N., Sagone, A. L., 1977, Effect of phagocytosis on the reduced soluble sulfhydril content of human granulocytes, Blood 50:1023.

    PubMed  CAS  Google Scholar 

  • Morton, D. J., Moran, J. F., and Stjernholm, R. L., 1969, Carbohydrate metabolism in leukocytes. XI. Stimulation of eosinophils and neutrophils, J. Reticubendothel. Soc. 6:525.

    CAS  Google Scholar 

  • Nakagawara, A., Takeshige, K., and Minakami, S., 1974, Induction of a phagocytosis-like metabolic pattern in polymorphonuclear leucocytes by cytochalasin E, Exp. Cell Res. 87:392.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, M., Nakamura, M. A., Okamura, J., and Kobajashi, Y., 1978, A rapid and quantitative assay of phagocytosis-connected oxygen consumption by leukocytes in whole blood, J. Lab. Clin. Med. 91:568.

    PubMed  CAS  Google Scholar 

  • Nathan, C. F., and Root, R. K., 1977, Hydrogen peroxide release from mouse peritoneal macrophages. Dependence on sequential activation and triggering, J. Exp. Med. 146:1648.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson, G. L., 1973, Anionic sites of human erythrocyte membranes. I. Effects of trypsin, phos-pholipase C., and pH on the topography of bound positively charged colloidal particles, J. Cell Biol. 57:373.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson, G. L., 1976. Transmembrane control of the receptors on normal and tumor cells. I. Cytoplasmic influence over cell surface components Biochim. Biophys. Acta 457:57.

    Article  PubMed  CAS  Google Scholar 

  • Noseworthy, J., and Karnovsky, J. L., 1972, Role of peroxide in the stimulation of the hexose monophosphate shunt during phagocytosis by polymorphonuclear leukocytes, Enzyme 13:110.

    PubMed  CAS  Google Scholar 

  • Ohnishi, S., and Ito, T., 1974, Calcium-induced phase separations in phosphatydil serine-phosphatidylcholine membranes, Biochemistry 13:881.

    Article  CAS  Google Scholar 

  • Oliver, J. M., Ukena, T. E. and Berlin, R. D., 1974, Effects of phagocytosis and colchicine on the distribution of lectin-binding sites on cell surfaces, Proc. Natl. Acad. Sci USA 71:394.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., and Dri, P., 1976, The NADPH oxidase activity of polymorphonuclear neutrophilic leucocytes revisited, in: The Reticuloendothelial System in Health and Disease (S. M. Reichard, M. R. Escobar, and H. Friedman, eds.), p. 151, Plenum Press, New York.

    Chapter  Google Scholar 

  • Patriarca, P., Zatti, M., Cramer, R., and Rossi, F., 1970, Stimulation of the respiration of polymorphonuclear leukocytes by phospholipase C, Life Sciences (Part I) 9:841.

    Article  CAS  Google Scholar 

  • Patriarca, P., Cramer, R., Marussi, M., Moncalvo, S., and Rossi, F., 1971a, Phospholipid splitting and metabolic stimulation in polymorphonuclear leukocytes, J. Reticubendothel. Soc. 10:251.

    CAS  Google Scholar 

  • Patriarca, P., Cramer, R., Moncalvo, S., Rossi, F., Romeo, D., 1971b, Enzymatic basis of metabolic stimulation in leukocytes during phagocytosis: The role of activated NADPH oxidase, Arch. Biochem. Biophys. 145:255.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., Cramer, R., Dri, P., Fant, L., Basford, R. R., and Rossi, F., 1973, NADPH oxidizing activity in rabbit polymorphonuclear leukocytes: Localization in azurophilic granules, Biochem. Biophys. Res. Commun. 53:830.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., Dri, P., and Rossi, F., 1974a, Superoxide dismutase in leukocytes, FEBS Letters 43:247.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., Basford, R. E., Cramer, R., Dri, P., and Rossi, F., 1974b, Studies on the NADPH oxidizing activity in polymorphonuclear leukocytes. The mode of association with the granule membrane, the relationship to myeloperoxidase and the interference of hemoglobin with NADPH oxidase determination, Biochim. Biophys. Acta 362:221.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., Dri, P., Kakinuma, K., Tedesco, F., and Rossi, F., 1975, Studies on the mechanism of metabolic stimulation in polymorphonuclear leukocytes during phagocytosis. I. Evidence for superoxide anion involvement in the oxidation of NADPH2, Biochim. Biophys. Acta 385:380.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P., Cramer, R., and Dri, P., 1977, The present status of the subcellular localization of the NAD(P)H oxidase in polymorphonuclear leucocytes, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca and D. Romeo, eds.), pp. 167–174, Piccin Medical Books, Padua.

    Google Scholar 

  • Paul, B. B., and Sbarra, A. J., 1968, The role of the phagocytes in host-parasite interactions. XIII. The direct quantitative estimation of H2O2 in phagocytizing cell, Biochim. Biophys. Acta 156:168.

    Article  PubMed  CAS  Google Scholar 

  • Paul, B. B., Strauss, R. R., Jacobs, A. A., and Sbarra, A. J., 1970, Function of H2O2, myeloperoxidase and hexose monophosphate shunt enzymes in phagocytosing cells from different species, Infect. Immun. 1:338.

    PubMed  CAS  Google Scholar 

  • Paul, B. B., Strauss, R. R., Jacobs, A. A., and Sbarra, A. J., 1972, Direct involvement of NADPH oxidase with the stimulated respiratory and hexose monophosphate shunt activity in phacocytizing leucocytes, Exp. Cell Res. 73:456.

    Article  PubMed  CAS  Google Scholar 

  • Penniall, R., and Spitznagel, J. K., 1975, Chicken neutrophils: Oxidative metabolism in phagocytic cells devoid of myeloperoxidase, Proc. Natl. Acad. Sci. USA 72:5012.

    Article  PubMed  CAS  Google Scholar 

  • Reed, P. W., 1969, Glutathione and hexose monophosphate shunt in phagocytizing and hydrogen peroxide-treated rat leukocytes, J. Biol. Chem. 244:2459.

    PubMed  CAS  Google Scholar 

  • Reed, P. W., and Tepperman, J., 1969, Phagocytosis associated metabolism and enzymes in the rat polymorphonuclear leukocytes, Am. J. Physiol. 216:223.

    PubMed  CAS  Google Scholar 

  • Reiss, M., and Roos, D., 1978, Difference in oxygen metabolism of phagocytosing monocytes and neutrophils, J. Clin. Invest. 61:480.

    Article  PubMed  CAS  Google Scholar 

  • Repine, J. E., White, J. G., Clauson, C. C., and Holmes, B. M., 1974, The influence of phorbol myristate acetate on oxygen consumption of polymorphonuclear leukocytes, J. Lab. Clin. Med. 83:911.

    PubMed  CAS  Google Scholar 

  • Rest, R. F., and Spitznagel, J. K., 1977, Subcellular distribution of superoxide dismutases in human neutrophils. Influence of myeloperoxidase on the measurement of superoxide dismutase activity, Biochem. J. 166:145.

    PubMed  CAS  Google Scholar 

  • Rister, R. F., and Baehner, R. L., 1976, A comparative study of superoxide dismutase activity in polymorphonuclear leukocytes, monocytes and alveolar macrophages of the guinea pig, J. Cell Physiol 87:345.

    CAS  Google Scholar 

  • Rister, M., and Baehner, R. L., 1977, Effect of hypoxia on superoxide anion and hydrogen peroxide production by polymorphonuclear leucocytes and alveolar macrophages, Br. J. Haematol. 36:241.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, J., and Camacho, Z., 1967, Oxidation of NADPH by polymorphonuclear leucocytes during phagocytosis, Nature (London) 216:606.

    Article  CAS  Google Scholar 

  • Roberts, J., and Quastel, J. H., 1964, Oxidation of reduced triphosphopyridine nucleotide by guinea pig polymorphonuclear leucocytes, Nature (London) 202:85.

    Article  CAS  Google Scholar 

  • Romeo, D., Cramer, R., and Rossi, F., 1970, Use of l-anilino-8-naphthalene sulfonate to study structural transitions in cell membrane of PMN leucocytes, Biochem Biophys. Res. Commun. 41:582.

    Article  PubMed  CAS  Google Scholar 

  • Romeo, D., Zabucchi, G., Soranzo, M. R., and Rossi, F., 1971, Macrophage metabolism: Activation of NADPH oxidation by phagocytes, Biochem. Biophys. Res. Commun. 45:1056.

    Article  PubMed  CAS  Google Scholar 

  • Romeo, D., Zabucchi, G., Marzi, T., and Rossi, F., 1973a, Kinetic and enzymatic features of metabolic stimulation of alveolar and peritoneal macrophages challenged with bacteria, Exp. Cell Res. 78:423.

    Article  PubMed  CAS  Google Scholar 

  • Romeo, D., Zabucchi, G., and Rossi, F., 1973b, Reversible metabolic stimulation of polymorphonuclear leucocytes and macrophages by concanavalin A, Nature New Biol. 243:111.

    PubMed  CAS  Google Scholar 

  • Romeo, D., Jug, M., Zabucchi, G., and Rossi, F., 1974, Perturbation of leucocyte metabolism by non phagocytosable concanavalin A-coupled beads, FEBS Lett. 42:90.

    Article  PubMed  CAS  Google Scholar 

  • Romeo, D., Zabucchi, G., Jug, M., Miani, N., and Soranzo, M. R., 1975a, Concanavalin A as a probe for studying the mechanism of metabolic stimulation of leukocytes, in: Concanavalin A (T. K. Chowdhury and A. K. Weiss, eds.), pp. 261–271, Plenum Press, New York.

    Google Scholar 

  • Romeo, D., Zabucchi, G., Miani, N., and Rossi, F., 1975b, Ion movement across leukocyte plasma membrane and excitation of their metabolism, Nature 253:542.

    Article  PubMed  CAS  Google Scholar 

  • Romeo, D., Zabucchi, G., and Rossi, F., 1977, Surface modulation of oxidative metabolism of polymorphonuclear leucocytes, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 153–165, Piccin, Padua.

    Google Scholar 

  • Romeo, D., Zabucchi, G., Berton, G., and Schneider, C., 1978, Metabolic stimulation of polymorphonuclear leucocytes: Effects of tetravalent and divalent concanavalin A, J. Membr. Biol. 44:321.

    Article  PubMed  CAS  Google Scholar 

  • Roos, D., Homan-Müller, J. W. T., and Weening, R. S., 1976, Effect of cytochalasin B on the oxidative metabolism of human peripheral blood granulocytes, Biochem. Biophys. Res. Commun. 68:43.

    Article  PubMed  CAS  Google Scholar 

  • Root, R. K., and Metcalf, J. A., 1977a, H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: Studies with normal and cytochalasin B-treated cells, J. Clin. Invest. 60:1266.

    Article  PubMed  CAS  Google Scholar 

  • Root, R. K., and Metcalf, J. A., 1977b, Superoxide and hydrogen peroxide formation by human granulocytes: Inter-relationship and activation mechanisms, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 185–199, Picon, Padua.

    Google Scholar 

  • Root, R. K., Metcalf, J. A., Oshino, N., and Chance, B., 1975, H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors, J. Clin. Invest. 55:945.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, H., and Klebanoff, S. J., 1979, Hydroxyl radical generation by polymorphonuclear leukocytes measured by electron spin resonance spectroscopy, J. Clin. Invest. 64:1725.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., and Zatti, M., 1964, Changes in the metabolic pattern of polymorphonuclear leukocytes during phagocytosis, Br. J. Exp. Pathol. 45:548.

    PubMed  CAS  Google Scholar 

  • Rossi, F., and Zatti, M., 1966a, The mechanism of the respiratory stimulation during phagocytosis in polymorphonuclear leukocytes, Biochim. Biophys. Acta 113:395.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., and Zatti, M., 1966b, Effect of phagocytosis on the carbohydrate metabolism of polymorphonuclear leucocytes, Biochim. Biophys. Acta 121:110.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., and Zatti, M., 1968, Mechanism of the respiratory stimulation in saponine-treated leukocytes. The KCN insensitive oxidation of NADPH, Biochim. Biophys. Acta 153:296.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., Zatti, M., and Patriarca, P., 1969, H2O2 production during NADPH oxidation by the granule fraction of phagocytosing polymorphonuclear leucocytes, Biochim. Biophys. Acta 184:201.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., Patriarca, P., Romeo, D., 1971a, Sequence of events leading to the metabolic stimulation in PMN leucocytes during phagocytosis, in: The Reticuloendothelial System and Immune Phenomena (N. Di Luzio, ed.), pp. 191–208, Plenum Press, New York.

    Chapter  Google Scholar 

  • Rossi, F., Zatti, M., Patriarca, P., and Cramer, R., 1971b, Effect of specific antibodies on the metabolism of guinea pig polymorphonuclear leukocytes, J. Reticuloendothel. Soc. 9:67.

    PubMed  CAS  Google Scholar 

  • Rossi, F., Romeo, D., and Patriarca, P., 1972, Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages, J. Reticuloendother. Soc. 12:127.

    CAS  Google Scholar 

  • Rossi, F., Zabucchi, G., and Romeo, D., 1975, Metabolism of phagocytosing mononuclear phagocytes, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Fürth, ed.), pp. 441–462, Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Rossi, F., Patriarca, P., Romeo, D., and Zabucchi, G., 1976a, The mechanism of control of phagocytic metabolism, in: The Reticuloendothelial System in Health and Disease. Function and Characteristics (S. M. Reichard, M. R. Escobar, and H. Friedman, eds.), pp. 205–223, Plenum Press, New York.

    Chapter  Google Scholar 

  • Rossi, F., Romeo, D. and Patriarca, P., 1976b, Metabolic perturbation of the inflammatory cells, Agents Actions 6:50.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, F., Dri, P., Bellavite, P., and Zabucchi, G., 1979, Oxidative metabolism of inflammatory cells, in: Advances in Inflammation Research, Vol. 1 (G. Weissmann, ed.), pp. 139–155, Raven Press, New York.

    Google Scholar 

  • Rossi, F., Zabucchi, G., Dri, P., Bellavite, P., and Berton, G., 1980a, O2 ‒ and H2O2 production during the respiratory burst in alveolar macrophages, in: Macrophages and Lymphocytes. Nature, Functions and Interaction, Part A (M. R. Escobar and H. Friedman, eds.), pp. 53–74, Plenum Press, New York.

    Chapter  Google Scholar 

  • Rossi, F., Patriarca, P., Berton, G., and de Nicola, G., 1980b, Subcellular localization of the enzyme responsible for the respiratory burst in resting and PMA-activated leucocytes, in: The Significance of Superoxide and Superoxide Dismutase, Vol. 2, Biological and Clinical Aspects (W. H. Bannister and J. V. Bannister, eds.), Elsevier, New York.

    Google Scholar 

  • Ryan, G. B., Borysenko, J. Z., and Karnovsky, M. J., 1974, Factors affecting the redistribution of surface-bound concanavalin A on human polymorphonuclear leukocytes, J. Cell Biol. 62:351.

    Article  PubMed  CAS  Google Scholar 

  • Salin, M. L., and McCord, J. M., 1974, Superoxide dismutase in polymorphonuclear leukocytes, J. Clin. Invest. 53:1197.

    Article  Google Scholar 

  • Sbarra, A. J., and Karnovsky, M. L., 1959, The biochemical basis of phagocytosis. I. Metabolic changes during ingestion of particles by polymorphonuclear leukocytes, J. Biol. Chem. 234:1355.

    PubMed  CAS  Google Scholar 

  • Sbarra, A. J., Selvaraj, R. J., Paul, B. B., Mitchell, G. W., and Louis, F., 1977, Some newer insights of the peroxidase mediated antimicrobial system, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 295–304, Piccin Medical Books, Padua.

    Google Scholar 

  • Schell-Frederick, E., 1974, Stimulation of the oxidative metabolism of polymorphonuclear leucocytes by the calcium ionophore A23187, FEBS Letters 48:37.

    Article  PubMed  CAS  Google Scholar 

  • Segal, A. W., and Jones, O. T. G., 1978, Novel cytochrome b system in phagocytic vacuoles of human granulocytes, Nature 276:515.

    Article  PubMed  CAS  Google Scholar 

  • Segal, A. W., and Jones, O. T. G., 1979a, The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils, Biochem. J. 182:181.

    PubMed  CAS  Google Scholar 

  • Segal, A. W., and Jones, O. T. G., 1979b, Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate, Biochem. Biophys. Res. Commun. 88:130.

    Article  PubMed  CAS  Google Scholar 

  • Segal, A. W., and Jones, O. T. G., 1980, Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease, FEBS Letters 110:111.

    Article  PubMed  CAS  Google Scholar 

  • Segal, A. W., and Peters, T. J., 1976, Characterization of the enzyme defect in chronic granulomatous disease, Lancet 1:1363.

    Article  PubMed  CAS  Google Scholar 

  • Segal, A. W., and Peters, T. J., 1977, Analytical subcellular fractionation of human granulocytes with special reference to the localization of enzymes involved in microbicidal mechanisms, Clin. Sci. Mol. Med. 52:429.

    PubMed  CAS  Google Scholar 

  • Segal, A. W., Webster, D., Jones, O. T. G. and Allison, A. C., 1978, Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease, Lancet 12: 446.

    Article  Google Scholar 

  • Selvaraj, R. J., and Sbarra, A. J., 1967, The role of the phagocyte in host-parasite interactions. Vu. Di- and triphosphopyridine nucleotide kinetics during phagocytosis, Biochim. Biophys. Acta 141:243.

    Article  PubMed  CAS  Google Scholar 

  • Shinagawa, Y., Tanaka, C., Teradka, A., and Shinagawa, Y., 1966, A new cytochrome in neutrophilic granules of rabbit leucocyte, J. Biochem. (Tokyo) 59:622.

    CAS  Google Scholar 

  • Simberloff, M. S., and Elsbach, P., 1971, The interaction in vitro between polymorphonuclear leukocytes and mycoplasma, J. Exp. Med. 134:1417.

    Article  Google Scholar 

  • Simchowitz, L., Metha, J., and Spilberg, I., 1979, Chemotactic factor-induced superoxide radical generation by human neutrophils. Requirement for proteinase (esterase) activity, J. Lab. Clin. Med. 94:403.

    PubMed  CAS  Google Scholar 

  • Stahelin, H., Karnovsky, M. L., Farnham, A. E., and Smith, E., 1957, Studies on the interaction between phagocytes and tubercle bacilli. HI. Some metabolic effect in guinea pig associated with injection with tubercle bacilli, J. Exp. Med. 105:265.

    Article  PubMed  CAS  Google Scholar 

  • Stjernholm, R. L., 1968, The metabolism of leukocytes, Congr. Int. Soc. Hematol. 12, New York Plenary Session, 5:300.

    Google Scholar 

  • Stjernholm, R. L., and Manak, R. C., 1970, Carbohydrate metabolism in leukocytes. XIV. Regulation of pentose cycle activity and glycogen metabolism during phagocytosis, J. Reticubendothel. Soc. 8:550.

    CAS  Google Scholar 

  • Stjernholm, R. L., Burns, C., and Hohnadel, J. H., 1972, Carbohydrate metabolism of leukocytes, Enzyme 13:7.

    PubMed  CAS  Google Scholar 

  • Strauss, B. S., and Stetson, C. A., 1960, Studies on the effect of certain macromolecular substances on the respiratory activity of the leukocytes of peripheral blood, J. Exp. Med. 112:653.

    Article  PubMed  CAS  Google Scholar 

  • Takanaka, K., and O’Brien, P. J., 1975, Mechanism of H2O2 formation by leukocytes. Evidence for a plasma membrane location, Arch. Biochem. 169:428.

    Article  PubMed  CAS  Google Scholar 

  • Takeshige, K., Matsumoto, T., Shibata, R., and Minakami, S., 1979, Simple and rapid method for the diagnosis of chronic granulomatous disease, measuring hydrogen peroxide and superoxide anions released from leukocytes in whole blood, Clin. Chim. Acta 92:329.

    Article  PubMed  CAS  Google Scholar 

  • Tauber, A. I., and Babior, B. M., 1977, Evidence for hydroxyl radical production by human neutrophils, J. Clin. Invest. 60:374.

    Article  PubMed  CAS  Google Scholar 

  • Tauber, A. I. and Goetzl, E. J., 1978, Subcellular localization and solubilization of the superoxide-generating activities (SGA) of human neutrophils Blood 52 (Suppl. 1):128.

    Google Scholar 

  • Tauber, A. L, and Goetzl, E. J., 1979, Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization, Biochemistry 18:5576.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, R. B., Duffus, P. H., Raff, M. C., and de Pétris, S., 1971, Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by antiimmunoglobulin antibody, Nature New Biol. 233:225.

    Article  PubMed  CAS  Google Scholar 

  • Tedesco, F., Trani, S., Soranzo, M. R., and Patriarca, P., 1975, Stimulation of glucose oxidation in human polymorphonuclear leucocytes by C3-sepharose and soluble C567, FEBS Letters 51:232.

    Article  PubMed  CAS  Google Scholar 

  • Tsan, M. F., 1977, Stimulation of the hexose monophosphate shunt independent of hydrogen peroxyde and superoxide production in rabbit alveolar macrophages during phagocytosis, Blood 50:935.

    PubMed  CAS  Google Scholar 

  • Tsan, M. F., and Berlin, R. D., 1971, Effect of phagocytosis on membrane transport of nonelectro-lytes, J. Exp. Med. 134:1016.

    Article  PubMed  CAS  Google Scholar 

  • Unanue, E. R., Karnovsky, M. L., and Engers, H. D., 1973, Ligand-induced movement of lymphocyte membrane macromolecules. M. Relationship between the formation and fate of anti-Ig-surface complexes and cell metabolism, J. Exp. Med. 137:675.

    Article  PubMed  CAS  Google Scholar 

  • Van Oss, C. J., Gillman, C. F., and Newmann, A. W., 1975, Phagocytic Engulfment and Cell Adhesiveness as Cellular Surface Phenomena, Marcel Dekker, New York.

    Google Scholar 

  • Vogt, M. T., Thomas, C., Vassallo, C. L., Basford, R. E., and Gee, J. B. L., 1971, Glutathione-dependent peroxidative metabolism in the alveolar macrophages, J. Clin. Invest. 50:401.

    Article  PubMed  CAS  Google Scholar 

  • Weening, R. S., Wever, R., and Roos, D., 1975, Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes, J. Lab. Clin. Med. 85:245.

    PubMed  CAS  Google Scholar 

  • Weening, R. S., Roos, D., Van Shaik, M. L. J., Voetman, A. A., de Boer, M., and Loos, H. A., 1977, The role of glutathione in oxidative metabolism of phagocytic leukocytes. Studies in a family with glutathione reductase deficiency, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes (F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 277–283, Piccin Medical Books, Padua.

    Google Scholar 

  • Weinstein, J., and Bielski, B. H. J., 1979, Kinetics of the interaction of H02 and Of radical with hydrogen peroxide. The Haber-Weiss reaction, J. Am. Clin. Soc. 101:58.

    Article  CAS  Google Scholar 

  • Weiss, S. J., King, G. W., and Lo Buglio, A. F., 1977, Superoxide generation by human monocytes and macrophages, J. Clin. Invest. 60:370.

    Article  PubMed  CAS  Google Scholar 

  • Weissmann, G., Korchak, H. M., Perez, H. D., Smolen, J. E., Goldstein, I. M., and Hoffstein, S. T., 1979, The secretory code of neutrophil, J. Reticuloendothel. Soc. 26:687.

    PubMed  CAS  Google Scholar 

  • West, J., Morton, D. J., Esmann, V., and Stjernholm, L. R., 1968, Carbohydrate metabolism in leukocytes. VIII. Metabolic activities of the macrophages, Arch. Biochem. Biophys. 124:85.

    Article  PubMed  CAS  Google Scholar 

  • Zabucchi, G., Soranzo, M. R., Berton, G., Romeo, D. and Rossi, F., 1978, The stimulation of the oxidative metabolism of polymorphonuclear leukocytes: effect of colchicine and cytochalasin B, J. Reticuloendothel. Soc. 24:451.

    PubMed  CAS  Google Scholar 

  • Zatti, M., and Rossi, F., 1965, Early changes of hexose monophosphate pathway activity and of NADPH oxidation in phagocytizing leucocyte, Biochim. Biophys. Acta 99:557.

    Article  PubMed  CAS  Google Scholar 

  • Zatti, M., and Rossi, F., 1967, Relationship between glycolysis and respiration in surfactant-treated leucocytes, Biochim. Biophys. Acte 48:553.

    Google Scholar 

  • Zatti, M., Rossi, F., and Patriarca, P., 1968, The H2O2 production by polymorphonuclear leucocytes during phagocytosis, Experientia 24:669.

    Article  PubMed  CAS  Google Scholar 

  • Zurier, R. B., Hoffstein, S., and Weissmann, G., 1973, Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine, J. Cell. Biol. 58:27.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Patologia Generale, Università di Padova, Sede di Verona, Italy

    Filippo Rossi

  2. Istituto di Patologia Generale, Università di Trieste, Italy

    Pierluigi Patriarca

  3. Istituto di Chimica Biologica, Università di Trieste, Italy

    Domenico Romeo

Authors
  1. Filippo Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierluigi Patriarca
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Domenico Romeo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA

    Robert R. Strauss

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Rossi, F., Patriarca, P., Romeo, D. (1980). Metabolic Changes Accompanying Phagocytosis. In: Sbarra, A.J., Strauss, R.R. (eds) Biochemistry and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9134-4_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9134-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9136-8

  • Online ISBN: 978-1-4615-9134-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation