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Biochemistry and Metabolism pp 21–43Cite as

Attachment and Recognition Factors in the Interaction between Microbes and Mononuclear Phagocytes

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Abstract

Removal of microbes from the vascular system and from tissue sites is handled by cells of the monocyte-macrophage system, the mononuclear phagocytes. In vivo, this process is a complex one, referred to as “clearance.” Difficulties in interpreting removal of microbes or carbon particles from the vascular system are magnified by factors such as organ blood flow, changes in plasma constituents, and changes in cell populations (Saba, 1970). In spite of this complexity, studies have clearly shown the importance of mononuclear phagocytes in recognizing and removing particles from the mammalian host (Spector, 1970; North, 1970). These cells are effective because of their specialized surfaces for recognition of foreign antigens, as well as damaged and serum coated particles, and because of their functional ability to then ingest and digest the particles. This review will focus on those factors occurring at the mononuclear phagocyte surface which affect this attachment and recognition process.

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Authors and Affiliations

  1. Division of International Medicine, Cornell University Medical College, New York, New York, 10021, USA

    Thomas C. Jones & Gerald I. Byrne

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  1. Thomas C. Jones
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  2. Gerald I. Byrne
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  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA

    Robert R. Strauss

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Jones, T.C., Byrne, G.I. (1980). Attachment and Recognition Factors in the Interaction between Microbes and Mononuclear Phagocytes. In: Sbarra, A.J., Strauss, R.R. (eds) Biochemistry and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9134-4_2

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