Abstract
Myeloperoxidase (MPO), H2O2, and a halide form a powerful antimicrobial system which is effective against a variety of microorganisms. This system is also toxic to certain mammalian cells, namely, spermatozoa, erythrocytes, leukocytes, platelets, and tumor cells. This review (see also Klebanoff, 1975a; Klebanoff and Clark, 1978) will consider the properties of the MPO-mediated antimicrobial system and its role in the intracellular and extracellular toxicity of the polymorphonuclear leukocyte (PMN).
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Abbreviations
- cis-DBE:
-
cis-dibenzoylethylene
- CGD:
-
chronic granulomatous disease
- DABCo:
-
1,4-diazabicyclo[2.2.2]octane
- D20:
-
deuterium oxide
- DPF:
-
diphenylfuran
- HO2 :
-
perhydroxy radical
- LPO:
-
lactoperoxidase
- MPO:
-
myeloperoxidase
- O2· - :
-
superoxide anion
- 102 :
-
singlet oxygen
- OH·:
-
hydroxyl radical
- PMN:
-
polymorphonuclear leukocyte
- SOD:
-
superoxide dismutase
- T3 :
-
trriodothyronine
- T4 :
-
thyroxine.
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Klebanoff, S.J. (1980). Myeloperoxidase-Mediated Cytotoxic Systems. In: Sbarra, A.J., Strauss, R.R. (eds) Biochemistry and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9134-4_11
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