Abstract
Immune responses in mammals, such as the production of antibody or the rejection of foreign (i.e., non-self) tissue grafts, are the result of complex interactions among a variety of different cell types. The hallmarks of the mammalian immune system — specificity, inducibility, memory, and regulation — have been conclusively shown to be associated with lymphocytes (Gowans, 1970). The division of lymphocytes into two major classes, known as T cells (thymus-derived lymphocytes) and B cells (bone-marrow-derived, thymus-independent lymphocytes), has led to an appreciation of the central role of the T cells in virtually all immune responses. This chapter will explore the genetic and environmental influences that govern T-cell specificity and behavior, as well as some interactions by which T cells regulate immune responses.
Keywords
- Nominal Antigen
- Major Histocompatibility Complex Antigen
- Ly123 Cell
- Cytotoxic Effector Cell
- Antiidiotype Antibody
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Abbreviations
- B:
-
Bone-marrow-derived, thymus-independent
- BUdR:
-
5-bromodeoxyuridine
- CH :
-
Heavy-chain constant region
- DNP:
-
2,4-dinitrophenyl
- Ig:
-
Immunoglobulin
- MHC:
-
Major histocompatibility complex
- OVA:
-
Egg albumin
- SHI:
-
Pneumococcal Polysaccharide
- T:
-
Thymus-derived
- TNP:
-
2,4,6-trinitrophenyl
- VH:
-
Heavy-chain variable region
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Janeway, C.A. (1980). Idiotypes, T-Cell Receptors, and T-B Cooperation. In: Marchalonis, J.J., Cohen, N. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9131-3_7
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