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Salamanders and the Evolution of the Major Histocompatibility Complex

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Book cover Contemporary Topics in Immunobiology

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 9))

Abstract

All species of eutherian mammals and birds that have been systematically investigated possess one homologous system of closely linked gene loci that is intimately involved with the immune responses of that species (Götze, 1977). This gene cluster is called the major histocompatibility complex, or MHC. Products of genes within this complex induce differentiation of T cells, as measured by blast-cell transformation, clonal expansion, and the development of cytotoxic effectors. MHC gene products also induce B-cell differentiation, resulting in antibody production. Recently, the MHC has been recognized to be intimately involved in the recognition of a multiplicity of non-self antigenic determinants, with the acquisition of the T-cell repertoire, and with the cooperative interactions between subsets of T cells, between T and B cells, between lymphocytes and macrophages, and between cytotoxic effectors and their specific targets (Möller, 1978). Finally, constituent loci of the MHC are involved, either structurally or in some regulatory fashion, in the biosynthesis and activation of at least some components of the complement system (Meo et al., 1975; Lachman and Hobart, 1978).

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Authors and Affiliations

  1. Department of Microbiology, Division of Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Nicholas Cohen

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  1. Nicholas Cohen
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Editors and Affiliations

  1. Frederick Cancer Research Center, Frederick, Maryland, USA

    John J. Marchalonis

  2. University of Rochester, Rochester, New York, USA

    Nicholas Cohen

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© 1980 Plenum Press, New York

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Cohen, N. (1980). Salamanders and the Evolution of the Major Histocompatibility Complex. In: Marchalonis, J.J., Cohen, N. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9131-3_5

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  • DOI: https://doi.org/10.1007/978-1-4615-9131-3_5

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