Abstract
In previous communications, we described specific glomerular changes in genetically diabetic KK mice (1–4). These changes include an increase in mesangial matrix and thickening of the glomerular basement membrane. Increase in the mesangium was found as early as two months of age, which gradually progressed with aging (3–4). Similar findings were described by other investigators.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Treser, G., et al (1965). Glomerular lesions in a strain of genetically diabetic mice. Proc. Soc. Exp. Biol. Med. 129, 820.
Camerini-Davalos, R.A. (1970). Studies of vascular and other lesions in KK mice. Diabetologia 6, 324
Ehrenreich, T., et al (1973). In “Vascular and Neurological Changes in Early Diabetes” (R.A. Camerini-Davalos and H.S. Cole, eds.), pp. 271–280. Academic Press, New York.
Oppermann, W., et al (1973). In “Vascular and Neurological Changes in Early Diabetes” (R. A. Camerini-Davalos and H.S. Cole, eds.) pp. 281–290 Academic Press, New York
Oppermann, W. , et al (1976). Attempts to delay the progression of inherited vasculopathy. Ann. N.Y. Aca. Sci., 275, 348–362.
Reddi, A.S., et al (1977). Diabetic Microangiopathy in KK Mice II. Suppression of Glomerulosclerosis by Pyridinolcarbamate. Exp. Mol-Pathol. 26, 325.
Reddi, A.S., et al (1978). Diabetic microangiopathy in KK mice. III. Effect of prolonged glyburide treatment on glomerulosclerosis. Exp. Mol. Pathol. 29, 92.
Wehner, H., et al (1978). Influence of short-term insulin therapy on the mesangial structure in young KK mice. Nephron 22, 460.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Oppermann, W., Wehner, H., Reddi, A.S., Camerini-Davalos, R.A. (1979). Effect of Insulin Treatment on the Mesangial Structure of KK Mice. In: Camerini-Davalos, R.A., Hanover, B. (eds) Treatment of EARLY DIABETES. Advances in Experimental Medicine and Biology, vol 119. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9110-8_43
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9110-8_43
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9112-2
Online ISBN: 978-1-4615-9110-8
eBook Packages: Springer Book Archive