Abstract
In vitro experiments with cultured fetal pancreas have indicated that amino-acid enrichment of the culture medium stimulated the cellular growth of the fetal pancreatic rudiment (1). This was associated with a higher concentration of insulin per B cell, a larger diameter of insulin granules and a greater release of insulin after a glucose stimulus. However, while it is generally accepted that hormones and nutrients control β-cell function in the fetus, the role of the autonomic nervous system should also be emphasized. The preservation of parasympathetic innervation and the absence of orthosympathetic innervation in the cultured rat pancreatic rudiment might partially explain the high sensitivity of the tissue to the stimulatory effect of glucose on insulin release (2).
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© 1979 Plenum Press, New York
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de Gasparo, M., de Herdt, P., Hoet, J.J. (1979). Effect of Maternal Carbohydrate Intolerance on the Development of the Autonomic Innervation of the Fetal Rat Pancreas. In: Camerini-Davalos, R.A., Hanover, B. (eds) Treatment of EARLY DIABETES. Advances in Experimental Medicine and Biology, vol 119. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9110-8_17
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DOI: https://doi.org/10.1007/978-1-4615-9110-8_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9112-2
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