Abstract
The role of germinal centres in immune reactions has intrigued immunologists for almost a hundred years, since Flemming’s classical monograph of 1885 (1), and has been a central theme throughout this Conference series. Such interest derives from the implication of these structures in the following aspects of the immune response:
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1.
Expansion of population of immunocompetent cells (2,3)
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2.
Generation of B-memory cells (4)
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3.
Induction of immunological tolerance (5)
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4.
Long-term retention of antigen (6,7)
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5.
Multiple antigen retention (8)
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6.
Antibody production (7)
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7.
Feedback control of antibody production (9, 10)
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8.
Homing of Bursa-derived cells (11)
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9.
T-B cell interaction (12)
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10.
Antigen-B cell interaction (13)
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References
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Smithyman, A.M., Carr, K., Forman, D., White, R.G. (1979). Separation of Germinal Centres from Chicken Spleen. In: Müller-Ruchholtz, W., Müller-Hermelink, H.K. (eds) Function and Structure of the Immune System. Advances in Experimental Medicine and Biology, vol 114. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9101-6_6
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DOI: https://doi.org/10.1007/978-1-4615-9101-6_6
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