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Inhibition of Lipase Adsorption at Interfaces. Role of Bile Salts Micelles and Colipase

  • D. Lairon
  • G. Nalbone
  • H. Lafont
  • J. Leonardi
  • N. Domingo
  • J. C. Hauton
  • R. Verger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

Pancreatic lipase normally acts on triglycerides emulsified particles. This interfacial enzyme exerts its full activity in presence of biliary lipids, especially bile salts. Therefore, in the physiological concentration range, above the critical micellar concentration (CMC), bile salts hinder lipase adsorption at interfaces. (Vandermeers et al., 1975; Borgström, 1975; Chapus et al. 1975; Momsen and Brockman, 1976a). A protein cofactor, colipase, reverses this inhibition.

Keywords

Bile Salt Pancreatic Lipase Loaded Enzyme Critical Micellar Concentra Adsorbed Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • D. Lairon
    • 1
  • G. Nalbone
    • 1
  • H. Lafont
    • 1
  • J. Leonardi
    • 1
  • N. Domingo
    • 1
  • J. C. Hauton
    • 1
  • R. Verger
    • 2
  1. 1.Groupe de Recherches sur le Transport des LipidesI.N.S.E.R.M.MarseilleFrance
  2. 2.C.B.M.-C.N.R.S.Marseille Cedex 2France

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