Inhibition of Lipase Adsorption at Interfaces. Role of Bile Salts Micelles and Colipase
Pancreatic lipase normally acts on triglycerides emulsified particles. This interfacial enzyme exerts its full activity in presence of biliary lipids, especially bile salts. Therefore, in the physiological concentration range, above the critical micellar concentration (CMC), bile salts hinder lipase adsorption at interfaces. (Vandermeers et al., 1975; Borgström, 1975; Chapus et al. 1975; Momsen and Brockman, 1976a). A protein cofactor, colipase, reverses this inhibition.
KeywordsBile Salt Pancreatic Lipase Loaded Enzyme Critical Micellar Concentra Adsorbed Enzyme
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