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Enzyme Therapy XI: Immunologic Considerations for Replacement Therapy with Unentrapped, Erythrocyte- and Liposome-Entrapped Enzymes

  • R. J. Desnick
  • M. B. Fiddler
  • S. D. Douglas
  • L. D. S. Hudson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

Critical review of animal and human trials of enzyme therapy has identified the major obstacles which must be overcome before replacement therapy can become an effective therapeutic modality for selected inherited lysosomal storage diseases (1). A prime requisite is the development of entrapment strategies for enzyme administration which afford maximal protection to the exogenous enzyme from potential physiologic and immunologic inactivation; in addition, the enzyme carriers used must be non-immunogenic and biodegradable.

Keywords

Lysosomal Storage Disease Enzyme Therapy Liposome Surface Erythrocyte Surface Exogenous Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. J. Desnick
    • 1
  • M. B. Fiddler
    • 1
  • S. D. Douglas
    • 1
  • L. D. S. Hudson
    • 1
  1. 1.Departments of Pediatrics, Medicine, Genetics and Cell Biology and The Dight Institute of Human GeneticsUniversity of MinnesotaMinneapolisUSA

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