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Cellular Localization of Na+ K+-Dependent ATpase and of the Enzymes of Sulpholipid Metabolism in Rabbit Kidney

  • J. J. Helwig
  • J. Pieringer
  • L. L. Sarlieve
  • A. A. Farooqui
  • G. Rebel
  • P. Mandel
  • R. A. Pieringer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

In mammals, cerebroside 3-sulphate is known to occur preferentially in brain and kidney (1). Although considerable information is available on the metabolism of cerebroside 3-sulphate in animal tissues (2,3,4,5), their role in mammalian metabolism is still speculative. There are several lines of evidence to indicate that in myelin membrane cerebroside 3-sulphate is linked to the basic myelin proteins by ionic interactions and this sulpholipid probably acts as a structural stabilizer for the myelin sheaths of the nerve cell (6,7). Further, the occurence of cerebroside 3-sulphate in tissues rich in Na+, K+-dependent ATPase involved in active sodium ion transport has led Karlsson et al.(8,9) to suggest that cerebroside 3-sulphate is someway related to the transport of sodium ions.

Keywords

Basic Myelin Protein Adenosine Triphosphatase Rabbit Kidney Dependent ATPase Fers Sodium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

PAPS,

3′-phosphoadenosine - 5′-phos­phosulphate

Na+,

K+-ATPase sodium-potassium dependent adenosine triphosphatase

TLC,

Thin-Layer chromatography.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. J. Helwig
    • 1
    • 2
    • 3
  • J. Pieringer
    • 1
    • 2
    • 3
  • L. L. Sarlieve
    • 1
    • 2
    • 3
  • A. A. Farooqui
    • 1
    • 2
    • 3
  • G. Rebel
    • 1
    • 2
    • 3
  • P. Mandel
    • 1
    • 2
    • 3
  • R. A. Pieringer
    • 1
    • 2
    • 3
  1. 1.Service d’Urologie, Clinique Chirurgicale AFaculté de MédecineStrasbourgFrance
  2. 2.Centre de Neurochimie du CNRSStrasbourgFrance
  3. 3.School of Medicine, Department of BiochemistryTemple UniversityPhiladelphiaUSA

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