Cholesterol Oxidase as a Probe for Studying Membrane Composition and Organization
Lipid bilayers of biological membranes often contain sterols (mainly cholesterol) as a major component. Membrane cholesterol content has been examined in some detail and is often quantitated in relation to phospholipid concentration. The ratio of cholesterol to phospholipid appears to affect many physical and biological properties of a membrane (Cooper, 1977). Several model membrane systems are now providing a better understanding of the interaction at the molecular level of cholesterol and various phospholipids (Huang, 1977; Thompson and Huang, 197 8; Demel and DeKruijff, 1976). Such information may provide better insight into biological functions of cell membranes.
KeywordsBiological Membrane Cholesterol Oxidase Membrane Cholesterol Cholesterol Oxidation Viral Membrane
Unable to display preview. Download preview PDF.
- 19.Moore, N.F., Patzer, E.J., Barenholz, Y. and Wagner, R.R. (1977), Biochemistry, 16, in press.Google Scholar
- 20.Nelson, G.J. (1972), in Blood Lipids and Lipoproteins (G.J. Nelson, ed.), Interscience, N.Y. p. 517.Google Scholar
- 23.Shinitzky, M. and Barenholz, Y. (1978), Biochim. Biophys. Acta, in press.Google Scholar
- 25.Thompson, T.E. and Huang, C. (1978), in “The Physiological Basis for Disorders of Membranes” Andreoli, T.E., Hoffman, H.F. and Fannest, D.D. eds., Plenum Press, New York, in press.Google Scholar