Specificity of Some Exo- and Endo-ß-Galactosidases Toward Glycosphingolipids
The importance of the specific action of glycosidases for maintaining normal cell function has been reflected in the heritable diseases characterized by their absence. Our appreciation of the role of glycosidases in the biological system would be enhanced by a better understanding of their substrate specificity. In this communication, we wish to use the specificities of ß-galactosidases isolated from Escherichia coli, jack bean and human liver to point out that the conventional nomenclature for glycosidases based solely on their specificity toward the glycon moiety of the substrates is misleading and sometimes confusing. In addition, the specificity of endo-ß-galactosidase isolated from Escherichia freundii will be presented.
KeywordsHuman Liver United States Public Health Jack Bean Bovine Erythrocyte Normal Cell Function
Unable to display preview. Download preview PDF.
- 2.Wan, C.C., Li, S.-C., and Li, Y.-T., Manuscript in preparation.Google Scholar
- 3.Svennerholm, L. (1972) Methods Carbohyd. Chem. 6, 464–474.Google Scholar
- 4.Chien, J.L., Li, S.-C., and Li, Y.-T. in R.E. Harmon, editor, Cell Surface Carbohydrate Chemistry, Academic Press, in press.Google Scholar
- 5.H. Nakagawa, Li, S.-C., and Li, Y.-T., manuscript in prepara-tion.Google Scholar
- 7.Svennerholm, L., Mânsson, J.-E., and Li, Y.-T. (1973) J. Biol. Chem. 248 740–742.Google Scholar
- 8.Li, Y.-T. and Li, S.-C. (1976) J. Biol. Chem. 251 1159–1163.Google Scholar