Studies on Bovine Brain Membrane-Bound Neuraminidase (Sialidase)

  • K. Sandhoff
  • B. Pallmann
  • H. Wiegandt
  • W. Ziegler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)


Mammalian neuraminidases have been localised inside the lysosomes, in the cytosol as well as in the various membranes of the cell cytocavitary system (1). Brain tissue is especially rich in membrane-bound neuraminidase which reaches its highest specific activity in the plasma membranes isolated from synaptosomes (2, 3). This enzyme cleaves terminal N-acylneuraminic acid residues, predominantly from oligosialogangliosides, thereby degrading them to monosialogangliosides (4–5).


Nitrous Oxide Sialic Acid Water Soluble Substrate Membrane Particle Neuraminidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



(monosialo-gangliotetraitol): Galßl→3GalNAcßl→4Ga1[3←2αNeuAc]ß1→4[3H]sorbitol


(disialo-gangliotetraitol): Gal [3←2αNeuAc] ß1→3GalNAcß 1→4Gal (3←2αNeuAc)ß1→4[3H]sorbitol


Gangliotriaosylceramide (GgOse3Cer): Ga1NACß1→4Galß1→4Glc1→l’ceramide


(ganglioside II3 NeuAc GgOse4-Cer): Galßl→3GaiNACß1→4Ga1[3←2αNeuAc]ß1→4G1cß1→1’ceramide


(ganglioside II3 NeuAc-GgOse3-Cer): Ga1NAcß1→4Gal [3←2αNeuAc]ß1→4Glcß1→1’ceramide


(ganglioside IV3 NeuAc, II3 NeuAc-GgOse4-Cer): Gal [3←2αNeuAc]ß1→3GalNAcß1→4Gal [3←2αNeuAc]ß1→4Glcß1→1’ceramide


N-Acetylneuraminic acid




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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • K. Sandhoff
    • 1
  • B. Pallmann
    • 1
  • H. Wiegandt
    • 2
  • W. Ziegler
    • 2
  1. 1.Max-Planck-Institut für PsychiatrieMünchen 40W.-Germany
  2. 2.Institut für Physiologische Chemie IPhilipps-UniversitätMarburgW.-Germany

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