Action of Rat Brain Sialidase on Synaptic Membrane Components in Situ

  • Abraham Rosenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)


To provide further information on the characteristics of synaptic membrane sialidase, leading to some understanding of its biological role, we have examined the susceptibility of intrinsic sialo compounds of the synaptosomal membrane to the action of synaptic membrane sialidase in situ. Sialo compounds were labeled in vivo by the intracranial injection of radioactive N-acetylmannosamine during rapid synaptogenesis in rats (1) which is marked by ganglioside synthesis (2) and appearance of electrophysiological function (3). The high levels of sialo compounds and sialidase in mammalian nerve ending membranes lend importance to an understanding of their metabolism. Specific radioactive labeling has permitted sensitive and accurate observation of the behavior of intrinsic synaptic membrane sialidase and the various sialic acid-containing components.


Sialic Acid Barbituric Acid Synaptic Membrane Thin Layer Chromatogram Synaptosomal Membrane 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Abraham Rosenberg
    • 1
  1. 1.The Milton S. Hershey Medical CenterHersheyUSA

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