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Pathway for Hydrolysis of Plasmalogens in Brain

  • Lloyd A. Horrocks
  • Sheung Chun Fu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

The ethanolamine plasmalogens in brain have a substantial rate of turnover (Horrocks et al., 1976). Hydrolytic degradation of the plasmalogen molecule could begin at any position. Evidence for phospholipase C (EC 3.1.4.3) in brain has been reported (Williams et al., 1973; Abra and Quinn, 1975). Diglycerides can also be released by reversal of ethanolamine phosphotransferase (EC 2.7.8.1) in the presence of CMP. Brain contains phospholipase A2 but its activity is much less with plasmalogens than with diacyl phosphoglycerides (Woelk and Porcellati, 1973). Plasmalogenase (EC 3.3.2.–) cleaves the alk-1-enyl group to release a long-chain aldehyde. None of these enzymes, except plasmalogenase, seem to possess the activity necessary to account for the turnover of ethanolamine plasmalogens.

Keywords

Vinyl Ether Saline Extract Cerebral White Matter Neuronal Perikaryon Cerebral Gray Matter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Lloyd A. Horrocks
    • 1
  • Sheung Chun Fu
    • 1
  1. 1.Dept. of Physiol. Chem.The Ohio State UniversityColumbusUSA

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