Abstract
The ethanolamine plasmalogens in brain have a substantial rate of turnover (Horrocks et al., 1976). Hydrolytic degradation of the plasmalogen molecule could begin at any position. Evidence for phospholipase C (EC 3.1.4.3) in brain has been reported (Williams et al., 1973; Abra and Quinn, 1975). Diglycerides can also be released by reversal of ethanolamine phosphotransferase (EC 2.7.8.1) in the presence of CMP. Brain contains phospholipase A2 but its activity is much less with plasmalogens than with diacyl phosphoglycerides (Woelk and Porcellati, 1973). Plasmalogenase (EC 3.3.2.–) cleaves the alk-1-enyl group to release a long-chain aldehyde. None of these enzymes, except plasmalogenase, seem to possess the activity necessary to account for the turnover of ethanolamine plasmalogens.
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Horrocks, L.A., Fu, S.C. (1978). Pathway for Hydrolysis of Plasmalogens in Brain. In: Gatt, S., Freysz, L., Mandel, P. (eds) Enzymes of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9071-2_37
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DOI: https://doi.org/10.1007/978-1-4615-9071-2_37
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