A Study on the Turnover of Rat Brain Phosphatidic Acid through the Glycerol-Phosphate Pathway
Phosphatidic acid can be synthesized de novo by two different pathways, usually named “glycerol-3-phosphate pathway” (1,2) and “acyl-dihydroxyacetone-phosphate pathway” (3). A study of the contribution of each one of these pathways to the synthesis of phosphatidic acid in vivo presents many difficulties, due to the high activity of brain diglyceride kinase (4,5,6). In addition, an in vivo study does not easily distinguish the mitocondrial and microsomal synthesis as well as the transfer of the newly formed molecules from one type of membrane to the other.
KeywordsMolecular Species Phosphatidic Acid Trace Trace Acid Dimethyl Ester Tidic Acid
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