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The Effects of Amphiphilic Compounds on Phosphatidate Metabolism

  • David N. Brindley
  • Mariana Bowley
  • R. Graham Sturton
  • P. Haydn Pritchard
  • June Cooling
  • Susan L. Burditt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Summary

Amphiphilic cations interact with phosphatidate and thereby change its physical properties. This interaction can redirect phospholipid metabolism. In the presence of Mg2+ amphiphilic cations inhibit the activity of phosphatidate phosphohydrolase and stimulate that of phosphatidate cytidylyltransferase. Increasing the concentration of Mg2+ further or adding Ca2+ have similar effects, except that Ca2+ does not stimulate phosphatidate cytidylyltransferase activity. Amphiphilic anions reverse the effects caused by the amphiphilic cations. The implication of these results are discussed in relation to the pharmacological effects of amphiphilic cationic drugs.

Keywords

Acidic Phospholipid AMPHIPHILIC Compound Triacylglycerol Synthesis Amphiphilic Cation Glycerolipid Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vavrečka, M., Mitchell, M.P. and Hübscher, G. Biochem. J. 115, 139–145 (1969)PubMedGoogle Scholar
  2. 2.
    Mangiapane, E.H., Lloyd-Davies, K.A. and Brindley, D.N. Biochem. J. 134, 103–112 (1973)PubMedGoogle Scholar
  3. 3.
    Whiting, P.H., Bowley, M., Sturton, R.G., Pritchard, P.H., Brindley, D.N. and Hawthorne, J.N. Biochem. J. in the pressGoogle Scholar
  4. 4.
    Lamb, R.G. and Fallon, H.J. Biochim. Biophys. Acta 348, 179188 (1974)Google Scholar
  5. 5.
    Fallon, H.J., Barwick, J., Lamb, R.G. and van den Bosch, H. J. Lipid Res. 16, 107–115 (1975)PubMedGoogle Scholar
  6. 6.
    Lamb, R.G. and Fallon, H.J. Fed. Proc. Fed. Amer. Soc. Exp. Biol. 36, 286A (1977)Google Scholar
  7. 7.
    Pritchard, H.P. and Brindley, D.N. J. Pharm. Pharmac. 29, in the press (1977)Google Scholar
  8. 8.
    Pritchard, P.H., Bowley, M., Sturton, R.G., Lawson, N., Glenny, H.P., Burditt, S.L., Cooling, J. and Brindley, D.N. Biochem. J. in the pressGoogle Scholar
  9. 9.
    Jamdar, S.C., Shapiro, D. and Fallon, H.J. Biochem. J. 158, 327–334 (1976)PubMedGoogle Scholar
  10. 10.
    Fallon, H.J., Lamb, R.G. and Jamdar, S.C. Biochem. Soc. Trans. 5, 37–40 (1977)Google Scholar
  11. 11.
    Yagihara, Y., Bleasdale, J.E. and Hawthorne, J.N. J. Neurochem. 21, 173–190 (1973)PubMedCrossRefGoogle Scholar
  12. 12.
    Schacht, J. and Agranoff, B.W. Biochem. Biophys. Res. Commun. 50, 934–941 (1973)Google Scholar
  13. 13.
    Schacht, J. and Agranoff, B.W. J. Biol. Chem. 249, 1551–1557 (1974)Google Scholar
  14. 14.
    Tzur, R. and Shapiro, B. Eur. J. Biochem. 64, 301–305 (1976)Google Scholar
  15. 15.
    Brindley, D.N. and Bowley, M. Postgrad. Med. J. 51 (Suppl.l) 91–95 (1975)Google Scholar
  16. 16.
    Brindley, D.N. and Bowley, M. Biochem. J. 148, 461–469 (1975)PubMedGoogle Scholar
  17. 17.
    Sanderson, R.F., Dodds, P.F. and Brindley, D.N. Biochem. Soc. Trans. 5, 295–296 (1977)Google Scholar
  18. 18.
    Bowley, M., Cooling, J., Burditt, S.L. and Brindley, D.N. Biochem. J. in the press (1977)Google Scholar
  19. 19.
    Brindley, D.N., Allan, D. and Michell, R.H. J. Pharm. Pharmac. 27, 462–464 (1975)CrossRefGoogle Scholar
  20. 20.
    Brindley, D.N., Bowley, M., Sturton, R.G., Pritchard, P.H., Burditt, S.L. and Cooling, J. Biochem. Soc. Trans. 5, 40–44 (1977)Google Scholar
  21. 21.
    Eichberg, J. and Hauser, G. Biochem. Biophys. Res. Commun. 60, 1460–1467 (1974)PubMedCrossRefGoogle Scholar
  22. 22.
    Hauser, G. and Eichberg, J. J. Biol. Chem. 250, 105–112 (1975)Google Scholar
  23. 23.
    Allan, D. and Michell, R.H. Biochem. J. 148, 471–478 (1975)PubMedGoogle Scholar
  24. 24.
    Abdel-Latif, A.A. and Smith, J.P. Biochem.Pharmac. 25, 1697–1704 (1976)CrossRefGoogle Scholar
  25. 25.
    Bazân, N.G., Ilincheta de Boschero, M.G., Giusto, N.M. and Pascual de Bazaán, H.E. in Adv. Exp. Med. Biol. (edited by Porcellati, G., Amaducci, L. and Galli, C.) vol. 72, pp. 139148, Plenum Publ. Corp., New York, (1976)Google Scholar
  26. 26.
    Wurster, N., Elsbach, P., Rand, J. and Simon, E.J. Biochim. Biophys. Acta 248, 282–292 (1971)CrossRefGoogle Scholar
  27. 27.
    Sturton, R.G. and Brindley, D.N. Biochem. J. 162, 25–32 (1977)PubMedGoogle Scholar
  28. 28.
    Sluyterman, L.A.A. and Wijdenes, J. Biochim. Biophys. Acta 321, 697–699 (1973)CrossRefGoogle Scholar
  29. 29.
    Seppälä, A.J., Saris, N.E.L. and Gauffín, M.L. Biochem. Pharmac. 20, 305–313 (1971)CrossRefGoogle Scholar
  30. 30.
    Scherphof, G.L., Scarpa, A. and van Toorenenbergen, A. Biochim. Biophys. Acta 270, 226–240 (1972)PubMedCrossRefGoogle Scholar
  31. 31.
    Waite, M. and Sisson, P. Biochemistry 11, 3098–3105 (1972)PubMedCrossRefGoogle Scholar
  32. 32.
    Kunze, H., Bohm, E. and Vogt, W. Biochim. Biophys. Acta 360, 260–269 (1974)CrossRefGoogle Scholar
  33. 33.
    Scherphof, G. and Westenberg, H. Biochim. Biophys. Acta 398, 442–451 (1975)CrossRefGoogle Scholar
  34. 34.
    Hauser, H., Penkett, S.A. and Chapman, D. Biochim. Biophys. Acta 183, 466–475 (1969)PubMedCrossRefGoogle Scholar
  35. 35.
    Papahadjopoulos, D., Jacobson, K., Poste, G. and Shephard, G. Biochim. Biophys. Acta 394, 504–519 (1975)PubMedCrossRefGoogle Scholar
  36. 36.
    Carey, M.C., Híron, P.C. and Small, D.M. Biochem. J. 153, 519–531 (1976)PubMedGoogle Scholar
  37. 37.
    Dawson, R.M.C. and Hauser, G. in Calcium and Cellular Function (edited by Cuthbert, A.W. ) pp. 17–41, Macmillan, London (1970)Google Scholar
  38. 38.
    Ragazzi, M., Gorio, A. and Peluchetti, D. Experientia 31, 567–568 (1975)PubMedCrossRefGoogle Scholar
  39. 39.
    Brindley, D.N., Bowley, M., Sturton, R.G., Pritchard, P.H., Burditt, S.L. and Cooling, J. in Central Mechanisms of Anorectic Drugs (edited by Garatt.ini, S. and Samanin, R.) in the press, Raven Press, New YorkGoogle Scholar
  40. 40.
    Michell, R.H., Alan, D., Bowley, M. and Brindley, D.N. J. Pharm. Pharmac. 28, 331–332 (1976)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • David N. Brindley
    • 1
  • Mariana Bowley
    • 1
  • R. Graham Sturton
    • 1
  • P. Haydn Pritchard
    • 1
  • June Cooling
    • 1
  • Susan L. Burditt
    • 1
  1. 1.Department of BiochemistryUniversity Hospital and Medical SchoolNottinghamUK

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