Advertisement

Fatty Acid Biosynthesis during Brain Development

  • J. M. Bourre
  • S. Pollet
  • M. Paturneau-Jouas
  • N. Baumann
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

The role of fatty acids in membrane structure is very important; this is particularly true in brain where two highly differentiated membranes are operative: myelin and nerve endings. The former contains 10 times as much long chain sphingolipids as any other known structure: very long chain saturated and mono-unsaturated fatty acids are concentrated in myelin and their presence in the sheath confers to the membrane increased stability. Thus their biosynthesis is a fundamental event during the maturation of the brain and alteration in the activities of enzymes involved in very long chain fatty acids biosynthesis could have a profound effect on the integrity and stability of the myelin membrane.

Keywords

Stearic Acid Fatty Acid Biosynthesis Medium Chain Fatty Acid Fatty Acid Synthetase Lignoceric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dhopeswarkar G., Subramanian C. and Mead J.F. Biochim. Biophys. Acta 296, 257–263 (1973).CrossRefGoogle Scholar
  2. 2.
    Gozlan-Devillierre N., Baumann N. and Bourre J.M. C.R. Acad. Sci. 282, 1825–1828 (1975).Google Scholar
  3. 3.
    Brady R.O. J. Biol. Chem. 23, 3099–3103 (1960).Google Scholar
  4. 4.
    Boone S. and Wakil S. Biochemistry 17, 1470–1479 (1970).CrossRefGoogle Scholar
  5. 5.
    Hajra A. and Radin N. J. Lipid Res. 4, 448–453 (1963).PubMedGoogle Scholar
  6. 6.
    Pollet S., Bourre J.M. and Baumann N. C.R. Acad. Sci. 268, 21462149 (1969).Google Scholar
  7. 7.
    Paturneau-Jouas M., Baumann N. and Bourre J.M. Biochimie 58, 341349 (1976).Google Scholar
  8. 8.
    Pollet S., Bourre J.M., Chaix G., Daudu 0. and Baumann N. Biochimie 55, 333–341 (1973).CrossRefGoogle Scholar
  9. 9.
    Bourre J.M., Pollet S., Chaix G., Daudu 0. and Baumann N. Biochimie 55, 1473–1479 (1973).CrossRefGoogle Scholar
  10. 10.
    Sidman R., Dickie M. and Appel S. Science 144, 308 (1964).CrossRefGoogle Scholar
  11. 11.
    Bourre J.M., Pollet S., Dubois G. and Baumann N. C.R. Acad. Sci. 271, 1221–1223 (1970).Google Scholar
  12. 12.
    Goldberg IL, Schechter I. and Bloch K. Science 182, 497–499 (1973).PubMedCrossRefGoogle Scholar
  13. 13.
    Bourre J.M., Daudu 0. and Baumann N. Biochem. Biophys. Res. Commun. 63, 1027–1034 (1975).CrossRefGoogle Scholar
  14. 14.
    Seidel D., Nowoczeck G. and Jatzkewitz H. J. Neurochem. 25, 619–622 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    Bourre J.M., Daudu 0. and Baumann N. Biochim. Biophys. Acta 424, 1–7 (1976).CrossRefGoogle Scholar
  16. 16.
    Pullarkat R. and Reha H. J. Neurochem. 25, 607–610 (1975).PubMedCrossRefGoogle Scholar
  17. 17.
    Paturneau-Jouas M., Baumann N. and Bourre J.M. Biochem. Biophys. Res. Commun. 71, 1326–1334 (1976).PubMedCrossRefGoogle Scholar
  18. 18.
    Bourre J.M., Paturneau-Jouas M. and Baumann N. C.R. Acad. Sci. 283, 409–412 (1976).Google Scholar
  19. 19.
    Bourre J.M., Pollet S., Daudu 0. and Baumann N. Brain Res. 51, 225–239 (1973).CrossRefGoogle Scholar
  20. 20.
    Volpe J., Lyles T., Roncari D. and Vagelos P. J. Biol. Chem. 7, 2502–2513 (1973).Google Scholar
  21. 21.
    Bourre J.M., Daudu 0. and Baumann N. Biochimie 58, 1277–1279 (1976).CrossRefGoogle Scholar
  22. 22.
    Bourre J.M., Paturneau-Jouas M., Daudu 0. and Baumann N. Eur. J. Biochem. 72, 41–47 (1977).CrossRefGoogle Scholar
  23. 23.
    Baumann N., Bourre J.M., Jacque C. and Harpin M.L. J. Neurochem. 20, 753–759 (1973).PubMedCrossRefGoogle Scholar
  24. 24.
    Bourre J.M., Daudu 0. and Baumann N. J. Neurochem. 24, 10951097 (1975).Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. M. Bourre
    • 1
  • S. Pollet
    • 1
  • M. Paturneau-Jouas
    • 1
  • N. Baumann
    • 1
  1. 1.Laboratoire de NeurochimieINSERM U. 134, Hôpital de la SalpêtrièreParis Cédex 13France

Personalised recommendations