Abstract
The role of fatty acids in membrane structure is very important; this is particularly true in brain where two highly differentiated membranes are operative: myelin and nerve endings. The former contains 10 times as much long chain sphingolipids as any other known structure: very long chain saturated and mono-unsaturated fatty acids are concentrated in myelin and their presence in the sheath confers to the membrane increased stability. Thus their biosynthesis is a fundamental event during the maturation of the brain and alteration in the activities of enzymes involved in very long chain fatty acids biosynthesis could have a profound effect on the integrity and stability of the myelin membrane.
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Bourre, J.M., Pollet, S., Paturneau-Jouas, M., Baumann, N. (1978). Fatty Acid Biosynthesis during Brain Development. In: Gatt, S., Freysz, L., Mandel, P. (eds) Enzymes of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9071-2_2
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DOI: https://doi.org/10.1007/978-1-4615-9071-2_2
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