Calcium-Activated Hydrolysis of Triphosphoinositide in Synaptosomes

  • J. N. Hawthorne
  • H. D. Griffin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)


Dawson (1954) first showed that the polyphosphoinositides of brain were more readily labelled with 32P than the other phospholipids. Diphosphoinositide and triphosphoinositide are found in myelin and other plasma membrane structures of nerve tissue. Turnover of the 4- and 5-phosphates of triphosphoinositide is very rapid and until recently has seemed more important in axons than at synapses (Hawthorne & Kai, 1970). Acetylcholine, for instance, stimulates incorporation of phosphate into the phosphatidylinositol of synaptosomes from brain cortex but has a smaller, inhibitory effect on incorporation into the polyphosphoinositides (Schacht & Agranoff, 1972). However, Abdel-Latif et al. (1977) have shown recently that triphosphoinosítide of rabbit iris muscle is hydrolysed as a result of muscarinic cholinergic stimulation.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. N. Hawthorne
    • 1
  • H. D. Griffin
    • 1
  1. 1.Department of BiochemistryUniversity Hospital and Medical SchoolNottinghamEngland

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