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Chemical Modification of Crotalus Atrox Phospholipase A2 by Means of a Photolabile Phosphatidylethanolamine Analog

  • Kuo-Sen Huang
  • John H. Law
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)

Abstract

Although sequences have been reported for a number of pancreatic and venom phospholipase A2 enzymes, our knowledge of the interaction of these enzymes with their substrates is still very meager. There is general agreement (1,2) that a histidine residue plays a role in the catalytic reaction, but how it functions and what is the detailed course of the hydrolysis remains obscure. The necessary structural features for a compound to be a substrate have been known for some time (3,4), but we do not understand which of these features is involved in the protein-lipid interaction.

Keywords

Substrate Analog Photolysis Product Medium Pressure Mercury Lamp Venom Phospholipase Active Site Histidine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Kuo-Sen Huang
    • 1
  • John H. Law
    • 1
  1. 1.Department of BiochemistryUniversity of ChicagoChicagoUSA

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