Chemical Modification of Crotalus Atrox Phospholipase A2 by Means of a Photolabile Phosphatidylethanolamine Analog

  • Kuo-Sen Huang
  • John H. Law
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 101)


Although sequences have been reported for a number of pancreatic and venom phospholipase A2 enzymes, our knowledge of the interaction of these enzymes with their substrates is still very meager. There is general agreement (1,2) that a histidine residue plays a role in the catalytic reaction, but how it functions and what is the detailed course of the hydrolysis remains obscure. The necessary structural features for a compound to be a substrate have been known for some time (3,4), but we do not understand which of these features is involved in the protein-lipid interaction.


Substrate Analog Photolysis Product Medium Pressure Mercury Lamp Venom Phospholipase Active Site Histidine 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Kuo-Sen Huang
    • 1
  • John H. Law
    • 1
  1. 1.Department of BiochemistryUniversity of ChicagoChicagoUSA

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