Abstract
Although sequences have been reported for a number of pancreatic and venom phospholipase A2 enzymes, our knowledge of the interaction of these enzymes with their substrates is still very meager. There is general agreement (1,2) that a histidine residue plays a role in the catalytic reaction, but how it functions and what is the detailed course of the hydrolysis remains obscure. The necessary structural features for a compound to be a substrate have been known for some time (3,4), but we do not understand which of these features is involved in the protein-lipid interaction.
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References
Volwerk, J.J., Pieterson, W.A., and de Haas, G.H., 1974, Biochemistry 13: 1446.
Roberts, M.F., Deems, R.A., Mincey, T.C. and Dennis, E.A., 1977, J. Biol. Chem. 252: 2405.
van Deenen, L.L.M., and de Haas, G.H., 1963, Biochim. Biophys. Acta 70: 538.
Bonsen, P.P.M., de Haas, G.H., Pieterson, W.A. and van Deenen, L.L.M., 1972, Biochim. Biophys. Acta 270: 364.
Lagocki, J.W., Boyd, N.D., Law, J.H. and Kézdy, F.J., 1970, J.Am. Chem. Soc. 92: 2923.
Lagocki, J.W., Law, J.H. and Kézdy, F.J., 1973, J. Biol. Chem. 248: 580.
Shen, B.W., Tsao, F.H.C., Law, J.H. and Kézdy, F.J., 1975, J. Am. Chem. Soc. 97: 1205.
Verger, R., Mieras, M.C.E. and de Haas, G.H., 1973, J. Biol. Chem. 248: 4023.
Pieterson, W.A., Vidal, J.C., Volwerk, J.J. and de Haas, G.H., 1974, Biochemistry 13: 1455.
de Haas, G.H., Slotboom, A.J. and Verheij, H.M., 1977, in “Cholesterol Metabolism and Lipolytic Enzymes: (J. Polonovski, ed.), p. 191, Masson Publishing, New York.
Chakrabarti, P. and Khorana, H.G., 1975, Biochemistry 14: 5021.
Stoffel, W., Darr, W. and Salm, K.P., 1977, J. Physiol Chem. 358: 453.
Hachimori, Y., Wells, M.A. and Hanahan, D.J., 1971, Biochemistry 10: 4084.
Thomas, P.J. and Law, J.H., 1966, J. Lipid Res. 7: 453.
Lagocki, J.W., Emken, E.A., Law, J.H. and Kézdy, F.J., 1976, J. Biol. Chem. 251: 6001.
Searle, N.E., 1963, Org. Syn. Coll. 4: 424.
de Haas, G.H., Slotboom, A., Bonsen, P.P.M., Nieuwenhuizen, W., van Deenen, L.L.M., Maroux, S., Blouka, V. and Desnuelle, P., 1970, Biochim. Biophys. Acta 221: 54.
Heinrikson, R.L., Kruger, E.T. and Keim, P.S., 1977, J, Biol. Chem. 252: 4913.
Sigler, P.B., Blow, D.M., Matthews, B.W. and Henderson, R., 1968, J. Mol. Bio. 35: 143.
Hexter, C.S., and Westheimer, F.H., 1971, J. Biol. Chem. 246: 3928.
Bonsen, P.P.M., de Haas, G.H. and van Deenen, L.L.M., 1972, Biochim. Biophys. Acta 270: 364.
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© 1978 Plenum Press, New York
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Huang, KS., Law, J.H. (1978). Chemical Modification of Crotalus Atrox Phospholipase A2 by Means of a Photolabile Phosphatidylethanolamine Analog. In: Gatt, S., Freysz, L., Mandel, P. (eds) Enzymes of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9071-2_16
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DOI: https://doi.org/10.1007/978-1-4615-9071-2_16
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