Abstract
Some acute and chronic effects of opiates and of central depressants have been reviewed, in order that a comparison can be made between the actions of these drugs. Special emphasis has been given to opiate-induced changes at the neuronal level, which have been studied either by the direct microelectrophoretic application of drugs to single neurones or by application of drugs to the myenteric plexus/ longitudinal muscle preparation of the guinea pig ileum. Available evidence suggests that chronic exposure of nervous tissue to opiates as well as to central depressants causes changes in neuronal excitability, which become apparent upon withdrawal of the drug. Although opiates and central depressants cause similar changes they appear to do so by different mechanisms. Such differences between the mode of action of opiates and central depressants may provide an explanation for the differing chronic effects of these drugs.
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References
Adler, M.W., Lin, C., Smith, K.P., Tresky, R., and Gildenberg, P.J. Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats. Psychopharmacologia (Berl.), 35: 243–247, 1974.
Barker, J.L., and Gainer, G. Pentobarbital: selective depression of excitatory postsynaptic potentials. Science, 182:720–722, 1973.
Bergmann, M.C., Klee, M., and Faber, D.S. Different sensitivity to ethanol of three early transient voltage damp currents of Aplysia neurones. Pflügers Arch., 348:139–153, 1974.
Bläsig, J., Herz, A., Reinhold, K., and Zieglgänsberger, S. Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia (Berl.), 33:19–38, 1973.
Bradley, P.B., Briggs, I., Gayton, R.J., and Lambert, L.A. Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem. Nature, 261:425–426, 1976.
Bradley, P.B., and Dray, A. The effects of microiontophoretically applied morphine and transmitter substances in rats during chronic morphine treatment and after withdrawal from morphine. Brit. J. Pharmacol., 51:104–106, 1974.
Cardenas, H., and Ross, D.H. Morphine induced calcium depletion in discrete regions of rat brain. J. Neurochem., 24:487–493, 1975.
Collier, H.O.J. Tolerance, physical dependence and receptors. Advanc. in Drug Res., 3:171–188, 1966.
Cox, B., Ary, M., and Lomax, P. Changes in sensitivity to apomorphine during morphine dependence and withdrawal in rats. J Pharmacol. exp. Ther., 196:637–641, 1976.
Curtis, D.R., and Johnston, G.A.R. Amino acid transmitters in the mammalian central nervous system. Ergebn. d. Phys., Reviews of Physiol., 69:97–188, 1974.
Davies, J. Effects of morphine and naloxone on Renshaw cells and spinal interneurones in morphine dependent and non-dependent rats. Brain Res., 113:311–326, 1976.
Ehrenpreis, S., Greenberg, J., and Comaty, J.E. Mechanism of development of tolerance to injected morphine by guinea pig ileum. Life Sci., 17:49–54, 1975.
Eidelberg, E. Possible actions of opiates upon synapses, Progress in Neurobiology, 6:81–102, 1976.
Faber, D.S., and Klee, M. Ethanol suppresses collateral inhibition of the goldfish Mauthner cell. Brain Res., 104:347–353, 1976.
Frederickson, R.A., Norris, F.H., and Hewes, C.R. Effects of naloxone and acetylcholine on medial thalamic and cortical units. Life Sci., 17:81–82, 1975.
French, S.W., Palmer, D.S., Narod, M.E., Reid, P.E., and Ramey, C.W. Noradrenergic sensitivity of the cerebral cortex after chronic ethanol ingestion and withdrawal. J. Pharmacol, exp. Ther., 194:315–326, 1975a.
French, S.W., Palmer, D.S., and Narod, M.B. Effect of withdrawal from chronic ethanol injection on the cAMP response of cerebral cortical slices using the agonists histamine, serotonin and other neurotransmitters. Can. J. Physiol. Pharmacol., 53:248–255, 1975b.
Goldstein, A., and Goldstein, D.B. Enzyme expansion theory of drug tolerance and physical dependence. In A- Wikler (Eds.) The Addictive States, pp. 265–267. Baltimore, Williams & Wilkins Comp., 1968.
Goldstein, A., and Schulz, R. Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Brit. J. Pharmacol., 48:655–666, 1973.
Goldstein, D.B. Alcohol withdrawal reactions in mice: Effects of drugs that modify neurotransmission. J. Pharmacol, exp. Ther., 186:1–9, 1973.
Goldstein, D.B. Drug dependence as an adaptive response: Studies with ethanol in mice. In A.J. Mandell (Eds.) Neurobiological Mechanisms of Adaption and Behaviour, pp. 185–198. New York, Raven Press, 1975.
Goldstein, D.B. Pharmacological aspects of physical dependence on ethanol. Life Sci., 18: 553–562, 1976.
Greer, C.A., Alpern, H.F., and Collins, A.C. Increased CNS-sensitivity to Flurothyl as a measure of physical dependence in mice following morphine, phenobarbital and ethanol treatment. Life Sci., 18:1375–1382, 1976.
Harris, R.A., Yamamoto, H., Iwamoto, E.T., Loh, H.H., and Way, E.L. Calcium ion and neurotransmitters in morphine analgesia and tolerance. Proc. of 10th Congr. CINP, Quebec, 1976.
Haycock, V.K., and Rees, J.M.H. The effect of morphine pretreatment on the sensitivity of mouse and guinea-pig ileum to acetylcholine and to morphine. In H.W. Kosterlitz, H.O.J. Collier and J.E. Villarreal (Eds.) Agonist and Antagonist Actions of Narcotic Analgesic Drugs, pp. 235–239. London, Macmillan Press, 1972.
Herz, A., Bläsig, J., and Papeschi, R. Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome. Psychopharmacologia (Berl.), 39:121–143, 1974.
Hill, R.G., Pepper, C.M., and Mitchell, J.F. Depression of nociceptive and other neurones in the brain by iontophoretically applied met-enkephalin. Nature, 262:604–606, 1976.
Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A., and Morris, H.R. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature, 258:577–579, 1975.
Israel, Y., Carmichael, F.I., and Macdonald, J.A. Effects of ethanol on electrolyte metabolism and neurotransmitter release in the CNS. In M.M. Gross (Eds.) Alcohol Intoxication and Withdrawal. Ex-per. Studies II 59, pp. 55–64. New York, Plenum Press, 1975.
Jaffe, J.H., and Sharpless, S.K. Pharmacological denervation supersensitivity in the central nervous system: A theory of physical dependence. In A. Wikler (Eds.) The Addictive States, pp. 226–246. Baltimore, Williams & Wilkins Comp., 1968.
Kalant, H. Biological models of alcohol tolerance and physical dependence. In M.M. Gross (Eds.) Alcohol Intoxication and Withdrawal. Exper. Studies, pp. 3–14. New York, Plenum Press, 1973.
Kaneto, H. Inorganic ions: The role of calcium. In D. Clouet (Eds.) Narcotic Drugs, pp. 302–309. New York, Plenum Press, 1971.
Klee, M.R., Lee, K.C., and Park, M.R. Changes in cat motoneurone membrane properties with ethanol. Pflügers Arch., 355, Suppl., R 85, 1975.
Kosterlitz, H.W., and Waterfield, A.A. In vitro models in the study of structure-activity relationships of narcotic analgesics. Ann. Rev. Pharmacol., 15:29–47, 1975.
Krnjevic, K. Chemical nature of synaptic transmission in vertebrates. Physiol. Rev. 54:418–540, 1974a.
Krnjevic, K. Central actions of general anaesthetics. In M.J. Halsey, R.A. Millar, J.A. Sutten (Eds.) Molecular Mechanisms in General Anaesthetics, pp. 65–89. New York, Churchill-Livingston, 1974b.
Kuschinsky, K. Does chronic morphine treatment induce a supersensitivity of dopamine receptors in rat brain? Psychopharmacologia (Berl.), 42:225–229, 1975.
Lagerspetz, K.Y.H., Varvikko, T., and Tirri, R. Effects of intraventricular brain injections of neurotransmitters on colonic temperature in morphine-tolerant rats. Life Sci., 15:281–288, 1974.
Lai, H. Narcotic dependence, narcotic action and dopamine receptors. Life Sci., 17:483–496, 1975.
Martin, W.R. A homeostatic and redundancy theory of tolerance to and dependence on narcotic analgesics. In A. Wikler (Eds.) The Addictive States, pp. 206–225. Baltimore, Williams & Wilkins Comp., 1968.
North, R.A., and Tonini, M. Hyperpolarisation by morphine of myenteric neurones. In H.W. Kosterlitz (Eds.) Opiates and Endogenous Opioid Peptides, Amsterdam, Elsevier/North Holland, 1976.
Pert, C.B., and Snyder, S.H. Opiate receptor: Demonstration in nervous tissue. Science, 179:1011–1014, 1973.
Pollock, D., Muir, T.C., Macdonald, A., and Henderson, G. Morphine-induced changes in the sensitivity of the isolated colon and vas deferens of the rat. Europ. J. Pharmacol., 20:321–328, 1972.
Puri, S.K., and Lai, H. Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression. Psychopharmacologia (Berl.), 32:115–120, 1973.
Richards, CD. Observations on the mode of action of antiepileptic drugs. In H.F. Bradford and CD. Marsden (Eds.) Biochemistry and Neurology, pp. 185–193. London, Academic Press, 1976,
Ross, D.H., Medina, M.A., and Cardenas, H.L. Morphine and ethanol: Selective depletion of regional brain calcium. Science, 186:63–64, 1974.
Satoh, M., Zieglgänsberger, W., Fries, W., and Herz, A. Opiate agonist-antagonist interaction at cortical neurones of naive and tolerant/dependent rats. Brain Res., 82:378–382, 1974.
Satoh, M., Zieglgänsberger, W., and Herz, A. Interaction between morphine and putative excitatory neurotransmitters in cortical neurones in naive and tolerant rats. Life Sci., 17:75–80, 1975.
Satoh, M., Zieglgänsberger, W., and Herz, A. Supersensitivity of cortical neurones of the rat to acetylcholine and 1-glutamate following chronic morphine treatment. Naunyn-Schmiedeberg’s Arch. Pharmacol., 293:101–103, 1976a.
Satoh, M., Zieglgänsberger, W., and Herz, A. Actions of opiates upon single neurone activity in the cortex of naive and tolerant rats. Brain Res., 1976b, in press.
Schulz, R., Cartwright, Ch., and Goldstein, A. Reversibility of morphine tolerance and dependence in guinea pig brain and myenteric plexus. Nature, 251:329–331, 1974.
Schulz, R., and Goldstein A. Morphine tolerance and supersensitivity to serotonin in the myenteric plexus of the guinea-pig. Nature, 249:168–170, 1973.
Schulz, R., and Herz, A. Aspects of opiate dependence in the myenteric plexus of the guinea-pig. Life Sci., 1976a, in press.
Schulz, R., and Herz, A. The guinea-pig ileum as an in vitro model to analyse dependence liability of narcotic drugs. In H.W. Kosterlitz (Eds.) Opiates and Endogenous Opioid Peptides, Amsterdam, Elsevier/North Holland, 1976b.
Schulz, R., and Herz, A. Dependence liability of enkephalin in the myenteric plexus of the guinea-pig. Europ. J. Pharmacol., 1976c, in press.
Seeman, P. The membrane actions of anaesthetics and tranquilizers. Pharm. Rev., 24:583–655, 1972.
Vasquez, B.J., Overstreet, D.H., and Russell, R.W. Psychopharmacological evidence for increase in receptor sensitivity following chronic morphine treatment. Psychopharmacologia (Berl.), 38:287–302, 1974.
Walker, Don W., Hunter, B.E., and Riley, J. A behavioral and electrophysiological analysis of ethanol dependence in the rat. In M.M. Gross (Eds.) Alcohol Intoxication and Withdrawal. Exp. Studies II 59, pp. 353–372. New York, Plenum Press, 1975.
Wallgren, H. Neurochemical aspects of tolerance and dependence on ethanol. In M.M. Gross (Eds.) Alcohol Intoxication and Withdrawal. Exp. Studies, pp. 15–31. New York, Plenum Press, 1973.
Wallgren, H., and Barry, H. Cellular basis of ethanol action on the nervous system. In H. Wallgren and H. Barry (Eds.) Actions of Ethanol, Vol.1, Biochemical, Physiological and Psychological Aspects, A 5, pp. 209–273. New York, Elsevier, 1970.
Waterfield, A.A., Hughes, J., and Kosterlitz, H.W. Cross tolerance between morphine and methionine-enkephalin. Nature, 260:624–625, 1976.
Westfall, D.P. Nonspecific supersensitivity of the guinea-pig vas deferens produced by decentralization and reserpine treatment. Br. J. Pharmacol., 39:110–120, 1970.
Yarbrough, G.G., and Phillis, J.W. Supersensitivity of central neurones — a brief review of an emerging concept. Can. J. Neurol. Sci., August, 147–152, 1975.
Zieglgänsberger, W., and Bayerl, H. The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat. Brain Res., 1976, in press.
Zieglgänsberger, W., and Fry, J.P. Actions of enkephalin on cortical and striatal neurones of naive and tolerant/dependent rats. In H.W. Kosterlitz (Eds.), Opiates and Endogenous Opioid Peptides. Amsterdam, Elsevier/North Holland, 1976.
Zieglgänsberger, W., Fry, J.P., Herz, A., Moroder, L., and Wünsch, E. Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent rats. Brain Res., 1976, in press.
Zieglgänsberger, W., and Satoh, M. The mechanism of inhibition by morphine on spinal neurones of the cat. Exp. Brain Res., 23, Suppl., Abstr. 444, 1975.
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Herz, A., Zieglgänsberger, W., Schulz, R., Fry, J.P., Satoh, M. (1977). Neuronal Aspects of Opiate Dependence and Tolerance in Comparison to Central Depressants. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal—IIIb. Advances in Experimental Medicine and Biology, vol 85B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9038-5_9
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DOI: https://doi.org/10.1007/978-1-4615-9038-5_9
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