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Chronic Alcohol Drinking and Subsequent Withdrawal in Rats Exposed to Different Diurnal Distributions of Schedule-Induction Sessions

  • R. M. Gilbert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)

Abstract

Eight rats drank large amounts of 6.25% alcohol as a consequence of daily exposure to 6 hours of schedule-induction sessions in “which a small food pellet was delivered every 90 sec. Rats having a 1-hr session every 4 hr showed slightly more withdrawal distress than rats having a 6-hr session every 24 hr. More significant may have been two different kinds of indication of possible loss of control over drinking by the inducing schedule. Rats experiencing six sessions a day did not drink water excessively when it replaced the alcohol solution. Rats experiencing one session a day drank half their total alcohol intake between sessions. If the schedule-induction procedure loses control over alcohol drinking, its chronic application to animals fails as a model of the factors that maintain excessive alcohol use in humans.

Keywords

Alcohol Consumption Alcohol Drinking Alcohol Solution Physical Dependence Audiogenic Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Cannon, D. S., Baker, T. B., Berman, R. F., and Atkinson, C. A. A rapid technique for producing ethanol dependence in the rat. Pharmacol. Biochem. Behav., 2:831–834, 1974.CrossRefGoogle Scholar
  2. Falk, J. L. Schedule-induced polydipsia as a function of fixed interval length. J. Exp. Anal. Behav., 9:37–39, 1966.CrossRefGoogle Scholar
  3. Falk, J. L., and Samson, H. H. Schedule-induced physical dependence on ethanol. Pharmacol. Rev., 27: 449–464, 1975.Google Scholar
  4. Falk, J. L., Samson, H. H., and Tang, M. Chronic ingestion techniques for the production of physical dependence on ethanol. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies, pp. 197–211. New York, Plenum Press, 1973.CrossRefGoogle Scholar
  5. Falk, J. L., Samson, H. H., and Winger, G. Behavioral maintenance of high levels of blood ethanol and physical dependence in the rat. Science, 177:811–813, 1972.CrossRefGoogle Scholar
  6. Falk, J. L., Samson, H. H., and Winger, G. Polydipsia-induced alcohol dependency in rats. Science, 192: 492, 1976.CrossRefGoogle Scholar
  7. Gilbert, R. M. Effects of ethanol on adjunctive drinking and barpressing under various schedules of reinforcement. Bull. Psychon. Soc., 1:l61-164, 1973.Google Scholar
  8. Gilbert, R. M. Schedule-induced ethanol polydipsia in rats with restricted fluid availability. Psychopharmacologia, 38:151–157, 1974.CrossRefGoogle Scholar
  9. Gilbert, R. M. Schedule-induced self-administration of drugs. In D. E. Blackman and D. J. Sanger (Eds.) Contemporary Research in Behavioural Pharmacology, London, Plenum Press, in press, 1976a.Google Scholar
  10. Gilbert, R. M. Dose division and debility in the production of ethanol withdrawal signs. Addiction Research Foundation (Substudy No. 753), 1976b.Google Scholar
  11. Goldstein, D. B. Quantitative study of alcohol withdrawal signs in mice. Ann. N. Y. Acad. Sci., 215:218–223, 1973.CrossRefGoogle Scholar
  12. Hawkins, T. D., Schrot, J. F., Githens, S. H., and Everett, P. B. Schedule-induced polydipsia: an analysis of water and alcohol ingestion. In R. M. Gilbert and J. D. Keehn (Eds.) Schedule Effects: Drugs, Drinking, and Aggression, pp. 95–128. Toronto, University of Toronto Press, 1972.Google Scholar
  13. Heintzelman, M. E., Best, J., and Senter, R.J. Polydipsia-induced alcohol dependency in rats: a reexamination. Science, 191:482–483, 1976.CrossRefGoogle Scholar
  14. Hunter, B. E., Walker, D. W., and Riley, J. N. Dissociation between physical dependence and volitional ethanol consumption: role of multiple withdrawal episodes. Pharmacol. Biochem. Behav., 2:523–529, 1974.CrossRefGoogle Scholar
  15. Hunter, B. E., Riley, J. IT., Walker, D. W., and Freund, G. Ethanol dependence in the rat: a parametric analysis. Pharmacol. Biochem. Behav., 3:6l9–629, 1975.CrossRefGoogle Scholar
  16. Kalant, H. Concluding remarks. In H. D. Cappell and A. E. Le Blanc (Eds.) Biological and Behavioural Approaches to Drug Dependence, pp. 169–174. Toronto, Addiction Research Foundation, 1975.Google Scholar
  17. Le Blanc, A. E., Gibbins, R. J., and Kalant, H. Generalization of behaviorally augmented tolerance to ethanol, and its relation to physical dependence. Psychopharmacologia, 44:241–246, 1975.CrossRefGoogle Scholar
  18. Majchrowitz, E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia, 43.:245–254, 1975.CrossRefGoogle Scholar
  19. McMillan, D. E., Leander, J. D., and Ellis, F. W. Consumption of ethanol and water under schedule-induced polydipsia (SIP). Pharmacologist, l6:303, 1974. (see note at end of ref. list).Google Scholar
  20. Meisch, R. A., Henningfield, J. E., and Thompson, T. Establishment of ethanol as a reinforcer for rhesus monkeys via the oral route: initial results. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies II, pp. 323–342. New York: Plenum Press, 1975.Google Scholar
  21. Samson, H. H., and Falk, J. L. Alteration of fluid Preference in ethanol-dependence animals. J. Pharmacol. Exp. Therap., 190: 365–376, 1974a.Google Scholar
  22. Samson H. H., and Falk, J. L. Ethanol and discriminative motor control: effects on normal and dependent animals. Pharmacol. Biochem. Behav., 2: 791–801, 1974h.CrossRefGoogle Scholar
  23. Samson, H. H., and Falk, J. L. Pattern of daily blood ethanol elevation and the development of physical dependence. Pharmacol. Biochem. Behav., 3:1119–1123, 1975.CrossRefGoogle Scholar
  24. Siegel, S. Evidence from rats that morphine tolerance is a learned response. J. Comp. Physiol. Psychol., 89:498–506, 1975.CrossRefGoogle Scholar
  25. Siegel, S. Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model. Science, 193: 323–325, 1976.CrossRefGoogle Scholar
  26. Staddon, J. E. R. Schedule-induced behavior. In W. K. Honig and J. E. R. Staddon (Eds.) Handbook of Operant Behavior, Englewood Cliffs, N. J., Prentice Hall, in press, 1976.Google Scholar
  27. Wallgren, H., and Barry, H., III. Actions of alcohol. Amsterdam, Elsevier, 1970.Google Scholar
  28. Note:- A more complete report of the study by McMillan, Leander, and Ellis (1974) has just been published. It isGoogle Scholar
  29. McMillan, D. E., Leander, J. D., Ellis, F. W., Lucot, J. B., and Frye, G. D. Characteristics of ethanol drinking patterns under schedule-induced polydipsia. Psychopharmacology, 49: 49–55, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. M. Gilbert
    • 1
  1. 1.Addiction Research FoundationTorontoCanada

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