Chronic Alcohol Drinking and Subsequent Withdrawal in Rats Exposed to Different Diurnal Distributions of Schedule-Induction Sessions

  • R. M. Gilbert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)


Eight rats drank large amounts of 6.25% alcohol as a consequence of daily exposure to 6 hours of schedule-induction sessions in “which a small food pellet was delivered every 90 sec. Rats having a 1-hr session every 4 hr showed slightly more withdrawal distress than rats having a 6-hr session every 24 hr. More significant may have been two different kinds of indication of possible loss of control over drinking by the inducing schedule. Rats experiencing six sessions a day did not drink water excessively when it replaced the alcohol solution. Rats experiencing one session a day drank half their total alcohol intake between sessions. If the schedule-induction procedure loses control over alcohol drinking, its chronic application to animals fails as a model of the factors that maintain excessive alcohol use in humans.


Alcohol Consumption Alcohol Drinking Alcohol Solution Physical Dependence Audiogenic Seizure 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. M. Gilbert
    • 1
  1. 1.Addiction Research FoundationTorontoCanada

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