The Toxicity of Ethanol. A Tentative Risk Evaluation

  • Ulf Rydberg
  • Staffan Skerfving
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)


A substantial knowledge has been collected on the dose-dependent toxic effects of ethanol. Whereas ethanol probably is the chemical substance exerting most toxic effects in many populations, a quantitative estimate of the upper limit of long term safe consumption from a toxicological and public health standpoint has not earlier been performed. It may be summarized that the toxic range of ethanol consumption is 35–200 g per day. Based on the available data we would propose an acceptable daily intake (ADI) for ethanol of 7 g per day. The practical consequences are discussed.


Ethanol Consumption Ethanol Exposure Fetal Alcohol Syndrome Technical Report Series Ethanol Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Alström, C.-H., Lindelius, R., Salum, I.: Alkoholism och mortalitet. Läkartidningen 71: 2049–52, 1974.Google Scholar
  2. Anstie, F. E.: On the dietetic and medicinal uses of wines. Practioner 4: 219–224, 1870.Google Scholar
  3. Ariyama, J., Skude, G., Wadstein, G. and Wehlin, L.: Alcohol pancreatitis in Sweden. Comparison of endoscopic pancreatography and serum amylase isoenzyme pattern. Stomach and Intestine, (Igaku Shoin, Tokio, Japan), 9/12, 1575–1583, 1974.Google Scholar
  4. Badr, F. M. and Badr, R. S.: Induction of dominant lethal mutation in male mice by ethyl alcohol. Nature 253: 134–136, 1975.CrossRefGoogle Scholar
  5. Becker, W. H.: Eine Maximaldosis des Alkohols. Therapeutische Monatshefte 22: 444–458, 1908.Google Scholar
  6. Beifrage, P., Berg, B., Cronholm, T., Elmqvist, D., Hägerstrand, I., Johansson, B., Nilsson-Ehle, P., Nordén, G., Sjövall, J., Wiebe, T.: Prolonged administration of ethanol to young healthy volunteers: Effects on biochemical, morphological and neurophysiological parameters. Acta Med Scand Suppl 552, 1–44, 1973.Google Scholar
  7. Bergman, H. and Ågren, G.: Cognitive style and intellectual performance in relation to the progress of alcoholism. Quart J Stud Alc 35: 1242–1255, 1974.Google Scholar
  8. Bjurulf, P., Sternby, N., Wistedt, B.: Definitions of alcoholism. Relevance of liver disease and temperance board registrations in Sweden. Quart J Stud Alc 32: 393–405, 1971.Google Scholar
  9. Brewin, T. B.: Alcohol intolerance in neoplastic disease. B Med J 2: 437–441, 1966.CrossRefGoogle Scholar
  10. Bruun, K. et al: Alcohol control policies in public health perspective. The Finnish Foundation for Alcohol Studies, Vol 25, 106 pp., 1975.Google Scholar
  11. Chesler, A., LaBelle, G. C., Himwich, H. E.: The relative effects of toxic doses of alcohol on fetal, newborn and adult rats. Quart J Stud Alc 3: 1–4, 1942.Google Scholar
  12. Cronholm, T.: Reduction of steroids during ethanol metabolism. Opusc Med Suppl 23, 1–24, 1972.Google Scholar
  13. Cronholm, T. and Sjövall, J.: Alkohol i metabolismen — överföring av väteatomerna. Läkartidningen 71: 1066–1068, 1974.Google Scholar
  14. Drew, G. C., Colquhoun, W. P., Long, H. A.: Effect of small doses of alcohol on a skill resembling driving. Br Med J 2: 993–998, 1958.CrossRefGoogle Scholar
  15. Fenna, D., Schefer, O., Mix, L.: Ethanol metabolism in various racial groups. Can Med Assoc J 105: 472–475, 1971.Google Scholar
  16. Flamant, R., Hayem, M., Lazar, P.: Cancer of the tongue. A study of 904 cases. Cancer 17: 377–385, 1964.CrossRefGoogle Scholar
  17. Goldberg, L.: Quantitative studies on alcohol tolerance in man. Acta Physiol Scand 5. Suppl 16. 1–128. 1943.CrossRefGoogle Scholar
  18. Goldberg, M., Hollstedt, C., Rydberg U.: Blodalkoholhalter efter förtäring av stora mängder lättöl och pilsner. Alkohol och narkotika 68: 15–19, 1974.Google Scholar
  19. Hall, C. A., Olson, K. B.: Alcohol-induced pain in Hodgkin’s disease. Quart J Stud Alc 253, 608–609, 1955.Google Scholar
  20. Hed, R., Lundmark, C., Dahlgren, H. and Orell, S.: Acute muscular syndrome in chronic alcoholics. Acta Med Scand 171: 285–599, 1962.Google Scholar
  21. Henefer, E.: Ethanol, 30 per cent, and hamsters pouch carcinoma. J Dent Res 45: 838–844, 1966.CrossRefGoogle Scholar
  22. Hollstedt, C., Rydberg, U.: Ethanol metabolism in the growing rat. Arch Int Pharmacodyn Thér 188, 341–348, 1970.Google Scholar
  23. Hollstedt, C. and Rydberg, U.: Alkoholen och den växande Organismen. Medicinska Riksstämman, Summaries, 288, 1973.Google Scholar
  24. Horie, A., Kohchi, S., Kuratsune, M.: Carcinogenesis in the esophagus. II. Experimental production of esophageal cancer by administration of ethanolic solution of carcinogens. Gann 56: 429–441, 1965.Google Scholar
  25. Jones, K. L.: The fetal alcohol syndrome. Addictive Diseases II, 79–88, 1975.Google Scholar
  26. Jones, K. L., Smith, D. W.: Recognition of the fetal alcohol syndrome in early infancy. Lancet ii: 999–1001, 1973.CrossRefGoogle Scholar
  27. Jones, K. L., Smith, D. W., Ulleland, C. N., Streissguth, A. P.: Pattern of malformation in offspring of chronic alcoholic mothers. Lancet i: 1267–1271, 1973.CrossRefGoogle Scholar
  28. Jones, K. L., Smith, D. W., Streissguth, A. P. and Myrianthopoulos, N. C.: Outcome in offspring of chronic alcohol women. Lancet i: 1076–1078, 1974.CrossRefGoogle Scholar
  29. Kager, L., Lindberg, S. and Ågren, G.: Alcohol consumption and acute pancreatitis in men. Scand J Gastroent 7 (Suppl 15): 1–38, 1972.CrossRefGoogle Scholar
  30. Kamionkowski, M. D., Fleshier, B.: The role of alcohol intake in esophageal carcinoma. Am J Med Sci 249: 696–700, 1965.CrossRefGoogle Scholar
  31. Keller, A. Z.: Cirrhosis of the liver, alcoholism and heavy smoking associated with cancer of the mouth and pharynx. Cancer 20: 1015–1022, 1967.CrossRefGoogle Scholar
  32. Ketcham, A. S., Wexler, H., Mantel, N.: Effects of alcohol in mouse neoplasia. Cancer Res 23: 667–670, 1963.Google Scholar
  33. Ledermann, S.: Influence de la consommation de vins et d’alcools sur les cancer, la tuberculouse pulmonaire et sur d’autres maladies. Sem Méd 28: 221–235, 1952.Google Scholar
  34. Leevy, C. M.: Hard liquor and cirrhosis. I: Alcoholic cirrhosis and other toxic hepatopathias. Skandia International Symposia, Stockholm, 1970 pp., 283–295, 313.Google Scholar
  35. Lelbach, W.: Organic pathology related to volume and pattern of alcohol use. In: “Research advances in alcohol and drug problems”, (eds R. J. Gibbins, Vol. 1, 93–198, 1974. John Wiley & Sons, New York, N. Y.Google Scholar
  36. Lelbach, W. K.: Cirrhosis in the alcoholic and its realtion to the volume of alcohol abuse. In: “Medical consequences of alcoholism” (ed F. A. Seixas, K. Williams and S. Eggleston). Ann N Y Acad Sci, vol. 252, 85–105, 1975.Google Scholar
  37. Lorber, S. H., Dinoso, W. P. and Chey, W. Y.: Diseases of the gastrointestinal tract. In: The Biology of Alcoholism (ed B. Kissin & H. Begleiter), vol. III. Clinical Pathology. Plenum Press, N.Y., 1974, p. 339–357.Google Scholar
  38. Myrhed, M.: Alcohol consumption in relation to factors associated with ischemic heart disease. A co-twin control study. Acta Med Scand, (suppl 567), 1–93, 1974.Google Scholar
  39. Naess, K.: Om etylalkohol som medikament. Tidsskr Nor Laegeforen 73: 179–182, 1952.Google Scholar
  40. Nygren, A.: Studier över alkoholmyopati. Opusc Med (suppl XXI), 1–16, 1971.Google Scholar
  41. Obe, G., Herha, J.: Chromosomal damage in chronic alcohol users. Human-genetik 29: 191–200, 1975.CrossRefGoogle Scholar
  42. Péquignot, G.: Les enquêtes par interrogatoire permettent-elles de déterminer la fréquence de l’étiologie alcoolique des cirrhoses du foie? Bull Natl Méd 147: 90–97, 1963.Google Scholar
  43. Péquignot, G.: About the geographical aspects of cirrhosis. In “Alcohol and the liver” (ed. W. Gerok, K. Sickinger and H. H. Hennekeuser). New York, N.Y., 1971.Google Scholar
  44. Rothman, K., Keller, A.: The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chron Diseases, 25: 711–716, 1972.CrossRefGoogle Scholar
  45. Rydberg, U.: Alkoholens roll i terapin. Läkartidningen 71: 1415–1417, 1974.Google Scholar
  46. Rydberg, U. and Skerfving, S.: Alkoholens giftighet: Ett försök till riskvärdering. Läkartidningen 71: 2275–2277, 1974.Google Scholar
  47. Salum, I.: Delirium tremens and certain other acute sequels of alcohol abuse. A comparative, clinical, social and prognostic study. Acta Psychiatr Scand Suppl 235, 1972.Google Scholar
  48. Sarles, H.: Cytotoxic effects of alcohol on the pancreas. In (M. M. Gross, ed.) Alcohol Intoxication and Withdrawal: Experimental Studies, III, Advances in Experimental Medicine and Biology, Plenum Press, New York, (In Press).Google Scholar
  49. Schmäl, D., Thomas, C., Sattler, W., Scheid, G. F.: Experimentelle Untersuchungen zur Syncarcinogenese. 3, Mitteilung. Versuche zur Krebserzeugung bei Ratten bei gleichzeitiger Gabe von Diäthylnitrosamin und Tetrakohlenstoff bzw. Äthylalkohol zugleich ein Experimenteller Beitrag zur Frage der Alkoholcirrhose. Z Krebsforsch 66: 526–532, 1965.CrossRefGoogle Scholar
  50. Sundby, P.: Alcoholism and mortality. Oslo: Universitetsforlaget, 1967, pp. 207.Google Scholar
  51. Wallgren, H., Barry, H. III: Actions of alcohol. Vol. I, II. Elsevier, 1–873, 1970.Google Scholar
  52. Wilkinson, P., Kornaczewski, A., Rankin, J. G., Santamaria, J. N.: Physical disease in alcoholism. Initial survey of 1.000 patients. Med J Australia, 1: 1217–1223, 1971.Google Scholar
  53. Wolff, P. H.: Ethnic differences in alcohol sensitivity. Science 175: 449–450, 1972.CrossRefGoogle Scholar
  54. WHO Technical Report Series: WHO Expert committee on Addiction-producing drugs. 13th report 273, 1964.Google Scholar
  55. WHO Technical Report Series: Procedures for investigating intentional and unintentional food additives, 348, 1967.Google Scholar
  56. WHO Technical Report Series: Evaluation of certain food additives and the contaminants mercury, lead and cadmium, 505, 1972.Google Scholar
  57. WHO Technical Report Series: Assessment of the carcinogenicity and mutagenicity of chemicals. Report of a WHO Scientific Group, 546, 1974.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Ulf Rydberg
    • 1
  • Staffan Skerfving
    • 2
  1. 1.Departments of Clinical and Theoretical Alcohol ResearchKarolinska InstitutetStockholmSweden
  2. 2.Department of Occupational MedicineUniversity Hospital of LundLundSweden

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