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Comparison of Ethanol Withdrawal Syndrome in Humans and Rats

  • Edward Majchrowicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)

Abstract

Physical dependence upon ehtanol induced in rats is in several respects similar to the tremulous and convulsive components of the ethanol withdrawal syndrome observed in man. These include short duration of the induction period, pattern of continuous ethanol consumption, rectilinear clearance of blood ethanol during prodromal detoxication phase and the onset of the ethanol dependence phase at relatively high blood ethanol concentrations. During the ethanol withdrawal period two phases are distinguished in both species: (1) Prodromal detoxication phase characterized by a spectrum of signs and responses of ethanol intoxication. (2) Ethanol dependence phase characterized by a spectrum of withdrawal signs and reactions. The successive onset and disappearance of the two sets of signs and reactions during both phases of the ethanol withdrawal period constitute a continuum of effects and responses and represent a reversal in the CNS function from the extremes of ethanol depression to the extremes of hyperexcitability.

Keywords

Induction Period Withdrawal Syndrome Physical Dependence Withdrawal Period Successive Onset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Edward Majchrowicz
    • 1
  1. 1.Laboratory of Basic Alcohol SciencesNational Institute on Alcohol Abuse and AlcoholismUSA

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