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Persistence of Brain Hyperexcitability Following Chronic Alcohol Exposure in Rats

  • Henri Begleiter
  • Bernice Porjesz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)

Abstract

Eighteen hooded Long-Evans rats were implanted with monopolar electrodes for the purpose of recording visual evoked potentials (VEP’s) at the following brain sites: visual cortex, reticular formation and thalamus. Baseline VEP’s were obtained to flashes for all animals, and subsequently twelve rats were intubated daily with a progression of increasing quantities of 20% (V/V) alcohol (3–8 g/kg), while the remaining six rats received an equivalent amount of water in the same fashion. Beginning 41/2 hours after the last dose of intubated alcohol, withdrawal VEP’s were sampled every half-hour up to 8 hours, and 24–27 hours postwithdrawal. All experimental animals manifested their greatest brain hyperexcitability at visual cortex, which peaked sharply between 7–8 hours after alcohol withdrawal. Following two weeks of abstinence, half of the experimental rats (N=6) and half of the controls (N=3) received an alcohol challenge dose (2 g/kg i.p.), while the remaining animals received the same challenge dose after five weeks. Marked hyperexcitability was observed in the two-week challenge dose animals that had been previously subjected to alcohol; no such increase in VEP amplitude was apparent for control rats. There is also some evidence of hyperexcitability after five weeks of abstinence from alcohol at visual cortex. The data indicates that the neurophysiological responses of post-addict rats to challenge doses of alcohol are readily distinguishable from those of naive animals, even five weeks after alcohol removal. Furthermore, alcohol seems to act differently at different sites of the brain.

Keywords

Visual Cortex Alcohol Withdrawal Alcohol Intoxication Challenge Dose Alcohol Withdrawal Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Henri Begleiter
    • 1
  • Bernice Porjesz
    • 1
  1. 1.Department of Psychiatry, Downstate Medical CenterS.U.N.Y.BrooklynUSA

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