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Role of Catecholamines in the Development of Tolerance to Barbiturates and Ethanol

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Alcohol Intoxication and Withdrawal—IIIb

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 85B))

Abstract

The destruction of noradrenergic systems in brain by administration of 6-hydroxydopamine prior to chronic ethanol treatment prevented the development of tolerance to ethanol. Animals pretreated with 6-hydroxydopamine also showed no cross tolerance to barbiturates. Destruction of noradrenergic systems prior to chronic treatment with barbiturates also partially prevented the development of tolerance to pentobarbital. 6-Hydroxydopamine pretreatment had little effect on the signs of physical dependence produced by ethanol. The possible dissociation of tolerance and dependence and the role of noradrenergic systems in these phenomena is discussed.

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Authors and Affiliations

  1. Department of Physiology, University of Illinois Medical Center, 901 South Wolcott, Chicago, Illinois, 60612, USA

    Boris Tabakoff, R. F. Ritzmann & Paula L. Hoffman

Authors
  1. Boris Tabakoff
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  2. R. F. Ritzmann
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  3. Paula L. Hoffman
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Editor information

Editors and Affiliations

  1. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Milton M. Gross

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© 1977 Plenum Press, New York

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Tabakoff, B., Ritzmann, R.F., Hoffman, P.L. (1977). Role of Catecholamines in the Development of Tolerance to Barbiturates and Ethanol. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal—IIIb. Advances in Experimental Medicine and Biology, vol 85B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9038-5_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9038-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9040-8

  • Online ISBN: 978-1-4615-9038-5

  • eBook Packages: Springer Book Archive

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