Role of Catecholamines in the Development of Tolerance to Barbiturates and Ethanol

  • Boris Tabakoff
  • R. F. Ritzmann
  • Paula L. Hoffman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)


The destruction of noradrenergic systems in brain by administration of 6-hydroxydopamine prior to chronic ethanol treatment prevented the development of tolerance to ethanol. Animals pretreated with 6-hydroxydopamine also showed no cross tolerance to barbiturates. Destruction of noradrenergic systems prior to chronic treatment with barbiturates also partially prevented the development of tolerance to pentobarbital. 6-Hydroxydopamine pretreatment had little effect on the signs of physical dependence produced by ethanol. The possible dissociation of tolerance and dependence and the role of noradrenergic systems in these phenomena is discussed.


Tyrosine Hydroxylase Chronic Ethanol Physical Dependence Noradrenergic Neuron Noradrenergic System 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Boris Tabakoff
    • 1
  • R. F. Ritzmann
    • 1
  • Paula L. Hoffman
    • 1
  1. 1.Department of PhysiologyUniversity of Illinois Medical CenterChicagoUSA

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