Opiate Receptors and Endogenous Opioid Peptides in Tolerance and Dependence

  • Hans W. Kosterlitz
  • John Hughes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)


The impact of the discovery of the endogenous opioid peptides, the enkephalins and endorphins, on our concepts of the mechanisms of tolerance to, and dependence on, opiates is discussed. After a brief survey of the chemistry of the opioid peptides, the possibility of an interaction between opiates and the peptides is considered and a hypothesis formulated. Experimental proof is presented as far as it has become available. The possible mechanisms involved in the development of tolerance and dependence for alcohol, barbiturates and opiates are compared briefly.


Opioid Peptide Opiate Receptor Potency Ratio Endogenous Opioid Peptide Antagonist Naloxone 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Hans W. Kosterlitz
    • 1
  • John Hughes
    • 1
  1. 1.Unit for Research on Addictive DrugsUniversity of AberdeenAberdeenScotland

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