Comments on: Oxygen Tension Sensors in Vascular Smooth Muscle
In assessing the effects of hypoxia in vascular smooth muscle (VSM), one often uses isometric force as an index of the energy available to the muscle and oxygen uptake as a measure of the cellular ATP production. Such interpretation, as with all biological models, is subject to shortcoming. I think it would be useful as a first step in the discussion to examine the relation between isometric force and ATP utilization under normoxic conditions where aerobic metabolism is not oxygen-diffusion limited.
KeywordsVascular Smooth Muscle Isometric Force Aerobic Glycolysis Isometric Tension Rabbit Aorta
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