Comments on: Oxygen Tension Sensors in Vascular Smooth Muscle

  • Richard J. Paul
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


In assessing the effects of hypoxia in vascular smooth muscle (VSM), one often uses isometric force as an index of the energy available to the muscle and oxygen uptake as a measure of the cellular ATP production. Such interpretation, as with all biological models, is subject to shortcoming. I think it would be useful as a first step in the discussion to examine the relation between isometric force and ATP utilization under normoxic conditions where aerobic metabolism is not oxygen-diffusion limited.


Vascular Smooth Muscle Isometric Force Aerobic Glycolysis Isometric Tension Rabbit Aorta 
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  1. 1.
    Paul, R.J. & Rüegg, J.C. (1976). Biochemistry of vascular smooth muscle: proteins of the contractile apparatus and their relationship to energy metabolism. In, Altura, B.M. & Kaley, G. (eds.) Microcirculation. University Park Press, Baltimore.Google Scholar
  2. 2.
    Namm, D.H. & Zucker, J.L. (1973). Biochemical alterations caused by hypoxia in the isolated rabbit aorta. Correlation with changes in arterial contractility. Circ. Res. 32:464–470.PubMedCrossRefGoogle Scholar
  3. 3.
    Needleman, P. & Blehm, D.J. (1970). Effect of epinephrine and potassium chloride on contraction and energy intermediates in rabbit thoracic aorta strips. Life Sci. 9: 1181–1189.CrossRefGoogle Scholar
  4. 4.
    Leblanc, P. & Clauser, H. (1974). ADP and Mg2+requirement for Ca2+accumulation by hog heart mitochondria. Correlation with energy coupling. Biochim. Biophys. Acta 347:87–101.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Richard J. Paul
    • 1
  1. 1.Department of PhysiologyUniversity CollegeLondonUK

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