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Oxygen Tension Sensors in Vascular Smooth Muscle*

  • R. F. Coburn
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)

Abstract

It is well documented in the literature that mechanical tension in at least some vascular smooth muscle preparations is sensitive to organ bath oxygen tension (1–4). Figure 1 illustrates the O2sensitivity of in vitrostrips of rabbit aorta as studied by Detar and Bohr (2), who have contributed to the characterization of this phenomenon. PO2dependent mechanical tension cannot be demonstrated in vascular smooth muscle which does not have spontaneous tension without adding an agonist to produce active tension. Most investigators have studied this phenomenon in arterial strips contracted with catecholamines. Identical PO2dependent mechanical tension, however, can be demonstrated in rabbit aorta with norepinephrine and with angiotensin contractions (5), suggesting that oxygen sensitivity is not due to effects of oxygen on release, uptake or metabolism of catecholamines.

Keywords

Vascular Smooth Muscle Oxygen Uptake Active Tension Organ Bath Rabbit Aorta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Carrier, O., Jr., Walker, J. R., and Guyton, A.C. Role of oxygen In autoregulation of blood flow in isolated vessels. Am. J. Physiol. 206: 951–954, 1964.PubMedGoogle Scholar
  2. 2.
    Detar, R., and Bohr, D.F. Oxygen and vascular smooth muscle contraction, Am. J. Physiol. 214: 241–244, 1968.PubMedGoogle Scholar
  3. 3.
    Fay, F.S. Guinea pig ductus arteriosus, I. Cellular and metabolic basis for oxygen sensitivity. Am. J. Phvsiol.221: 470–479, 1971.Google Scholar
  4. 4.
    Smith, D.J., and Vane, J.R. Effects of oxygen tension on vascular and other smooth muscle. J. Physiol. 186: 284–294, 1966.PubMedGoogle Scholar
  5. 5.
    Coburn, R.F., Grubb, B., and Aronson, R. Oxygen tension sensing in rabbit aorta. Submitted for publication,Google Scholar
  6. 6.
    Pittman, R.N., and Duling, B.R. Oxygen sensitivity of vascular smooth muscle, I. In Vitro studies. Microvascular Res. 6: 202–211, 1973.CrossRefGoogle Scholar
  7. 7.
    Chance, B., Oshino, N., Sugano, T., and Mayevsky, A. Basic principles of tissue oxygen determination from mitochondrial signals. In: Oxygen Transpart to Tissue, Plenum Press, New York, 1973, p. 277–291.Google Scholar
  8. 8.
    Finlayson, B., Lymn, R.W., and Taylor, E.W, Studies on the kinetics of formation and dissociation of the actomyosin complex. Biochem. 8: 811–819, 1969.CrossRefGoogle Scholar
  9. 9.
    Lymn, R.W., and Taylor, E.W. Transient state phosphate production in the hydrolysis of nucleoside triphosphates by myosin. Biochem. 9: 2975–2983, 1970.CrossRefGoogle Scholar
  10. 10.
    Shibata, S., and Briggs, A.H. Mechanical activity of vascular smooth muscle under anoxia. Am. J. Physiol. 212: 981–984, 1967.PubMedGoogle Scholar
  11. 11.
    Lundholm, L., and Mohme-Lundholm, E. Energetics of isometric and isotonic contraction in isolated vascular smooth muscle under anaerobic conditions. Acta Physiol. Scand.65: 275–282, 1965,CrossRefGoogle Scholar
  12. 12.
    Lundholm, L. and Mohme-Lundholm, E. Dissociation of contraction and stimulation of lactic acid production in experiments on smooth muscle under anaerobic conditions. Acta Physiol. Scand.57: 111–124, 1963.PubMedCrossRefGoogle Scholar
  13. 13.
    Needleman, P., and Blehm, D.J. Effect of epinephrine and potassium chloride on contraction and energy intermediates in rabbit thoracic aorta strips. Life Sciences9: 1181–1189, 1970.CrossRefGoogle Scholar
  14. 14.
    Peterson, J.W., and Paul, R.J. Aerobic glycolysis in vascular smooth muscle: relation to isometric tension, Biochem. et Biophys. Acta357: 167–176, 1974.CrossRefGoogle Scholar
  15. 15.
    Van Harn, G.L., Rubio, R., and Berne, R.M, Adenine nucleotide formation in vascular smooth muscle during hypoxia. The Physiologist19: 398, 1976.Google Scholar
  16. 16.
    Fay, F. Oxygen tension sensors in ductus arteriosis. This Symposium. 1976.Google Scholar
  17. 17.
    Kroeger, E., and Stephens, N.L. Effect of hypoxia on energy and calcium metabolism in airway smooth muscle. Am. J. Physiol. 220: 1199–1204, 1971.PubMedGoogle Scholar
  18. 18.
    Grubb, B. and Coburn, R.F. O2dependent mechanical tension. The Physiologist19: 212, 1976,Google Scholar
  19. 19.
    Laszt, L. Effect of potassium on muscle tension especially on that of vascular muscle. Nature185: 696, 1960,PubMedCrossRefGoogle Scholar
  20. 20.
    Yonetani, T. and Lay, G.S. Studies of cytochrome oxidase VI. Kinetics of the aerobic oxidation of ferrocytochrome c by cytochrome oxidase. J. Biol. Chem.240: 3392–3398, 1965.PubMedGoogle Scholar
  21. 21.
    Keilin, D., and Hartree, E.F. Cytochrome and cytochrome oxidase. Proc. Roy. Soc. London, Ser. B., 127: 167–191, 1939.CrossRefGoogle Scholar
  22. 22.
    Furchgott, R.F., Ehrreich, S.J., and Greenblatt, E. The photo-activated relaxation of smooth muscle of rabbit aorta. J. Gen. Physiol. 44: 499–519, 1961.PubMedCrossRefGoogle Scholar
  23. 23.
    Yamaguchi, H., Stephens, N.L., and Dhalla, N.S. Electrophsiological effects of hypoxia in tracheal smooth muscle. Fed. Proc.35: 776, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. F. Coburn
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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