Altered Mitochondrial Metabolism in Circulatory Shock

  • Leena Mela
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


Studies of mitochondrial function after circulatory shock, hemorrhagic or endotoxic, have revealed defective oxidative metabolism in several organs, such as the liver, kidney, and the brain (1,2,3). In this comment I would like to emphasize certain important aspects of these findings.


Mitochondrial Function Hemorrhagic Shock Adenine Nucleotide Translocase Circulatory Shock Mitochondrial Inhibition 
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  1. 1.
    Mela, L., Bacalzo, L. V., and Miller, L. D. Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock. Am. J. Physiol. 220:571–577, 1971.PubMedGoogle Scholar
  2. 2.
    Mela, L. Mitochondrial metabolic alterations in experimental circulatory shock. In Gram-Negative Bacterial Infections and Mode of Endotoxin Actions (Urbaschek, B., Urbaschek, R., and Neter, E., Eds.), pp. 288–295. Springer-Verlag, Wien, New York, 1975.CrossRefGoogle Scholar
  3. 3.
    Mela, L., Crowe, W., Harbig, K., Wrobel-Kuhl, K., and Kovach, A. G. B. Inhibition of brain mitochondrial function and changes of tissue H+ and K+ concentration in hemorrhagic shock. Surg. Forum 26:51, 1975.PubMedGoogle Scholar
  4. 4.
    Kovach, A. G. B. Cerebral hemodynamic and metabolic alterations in hypovolemic shock. This volume.Google Scholar
  5. 5.
    Mela, L., Harbig, K., Kovach, A. G. B., and Reivich, M. Response of brain mitochondria to hemorrhagic shock. J. Neurochem., submitted.Google Scholar
  6. 6.
    Mela, L., Hinshaw, L. B., and Coalsonm J. J. Correlation of cardiac performance, ultrastructural morphology, and mitochondrial function in endotoxemia in the dog. Circ. Shock 1:265–272, 1974.Google Scholar
  7. 7.
    Nicholas, G. G., Mela, L., and Miller, L. D. Early alterations in mitochondrial membrane transport during endotoxemia. J. Surg. Res. 16:375, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Ginsberg, M.D., Mela, L., Wrobel-Kuhl, K., and Reivich, M. Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil. Ann. Neurol., submitted.Google Scholar
  9. 9.
    Lefer, A. M. Role of myocardial depressant factor in the pathogenesis of circulatory shock. Fed. Proc. 29: 1836–1847, 1970.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Leena Mela
    • 1
  1. 1.Harrison Department of Surgical ResearchUniversity of PennsylvaniaPhiladelphiaUSA

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