Abstract
Dr. Silver is the world leader in the art of microelectrode construction. He has made important approaches to the question, “When in the course of hypoxia and ischemia does the nerve cell reach the point of irreversible injury?” Clearly this is some time after the arrival of zero PO2 in a stop flow experiment and is also after the arrest of spontaneous electrical activity which is now known to consist mainly of synaptic potentials, while the critical events probably occur in the cell body. Two of his measurements appear to come close to the critical point. These are the arrival of an intracellular pH of 6.7 and failure of the Na+- K+pump reflected in a high extracellular K+ of 20–30 mM.
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References
J. Halsey, S. Ganji, W. Erdmann, and H. Mardis: Studies in cerebral ischemia. Microvasc. Res. (in press), 1976.
R. Kelly, and J. Halsey: Comparison of local blood flow and oxygen availability at the same locus in the ischemic gerbil brain. STROKE 7:274–278, 1976.
E. Quayle, S. Christian, and J. Halsey: Effects of ischemia on the Mg++ requiring ATP-ase associated with neuronal synaptic vesicles in gerbil brain. STROKE 7:36–40, 1976.
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© 1977 Plenum Press, New York
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Halsey, J.H. (1977). Events Marking Irreversible Injury. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds) Tissue Hypoxia and Ischemia. Advances in Experimental Medicine and Biology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9035-4_27
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DOI: https://doi.org/10.1007/978-1-4615-9035-4_27
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