Events Marking Irreversible Injury

  • James H. HalseyJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


Dr. Silver is the world leader in the art of microelectrode construction. He has made important approaches to the question, “When in the course of hypoxia and ischemia does the nerve cell reach the point of irreversible injury?” Clearly this is some time after the arrival of zero PO2 in a stop flow experiment and is also after the arrest of spontaneous electrical activity which is now known to consist mainly of synaptic potentials, while the critical events probably occur in the cell body. Two of his measurements appear to come close to the critical point. These are the arrival of an intracellular pH of 6.7 and failure of the Na+- K+pump reflected in a high extracellular K+ of 20–30 mM.


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  1. 1.
    J. Halsey, S. Ganji, W. Erdmann, and H. Mardis: Studies in cerebral ischemia. Microvasc. Res. (in press), 1976.Google Scholar
  2. 2.
    R. Kelly, and J. Halsey: Comparison of local blood flow and oxygen availability at the same locus in the ischemic gerbil brain. STROKE 7:274–278, 1976.CrossRefGoogle Scholar
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    E. Quayle, S. Christian, and J. Halsey: Effects of ischemia on the Mg++ requiring ATP-ase associated with neuronal synaptic vesicles in gerbil brain. STROKE 7:36–40, 1976.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • James H. HalseyJr.
    • 1
  1. 1.Department of NeurologyUniversity of Alabama Medical CenterBirminghamUSA

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