Regional Changes in Metabolism in Hypoxia-Ischemia
The purpose of this study is to describe regional metabolic changes following an episode of cerebral ischemia in the cat. Regional characterization of metabolic derangements is imperative because it is unlikely that cerebral blood flow is uniformly reduced in most hypoxic-ischemic episodes.1, 2, 3 Furthermore, neurons in discrete anatomic regions such as hippocampus or arterial border zones4 are selectively vulnerable to hypoxia-ischemia. Consequently, we have investigated regional alterations of cerebral metabolites in a model of incomplete ischemia (oligemia).
KeywordsWhite Matter Gray Matter Metabolite Level Cortical Surface Subcortical White Matter
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