Metabolic Aspects of Cerebral Hypoxia-Ischemia

  • B. K. Siesjö
  • C.-H. Nordström
  • S. Rehncrona
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


This communication, which is focused on changes in brain metabolism in hypoxia and ischemia, briefly summarizes results obtained in this and other laboratories during the last 4–5 years. An attempt will be made to describe the characteristic features of hypoxic hypoxia, both at normal and at reduced perfusion pressures, as well as of incomplete and complete ischemia, and to discuss how the metabolic changes relate to irreversible neuronal damage. The references quoted are highly selective. For further references, and for a somewhat more detailed account of the topics discussed, the reader is referred to original papers quoted in the text and to some recent review articles (Nilsson et al. 1974, Siesjö et al. 1974, 1975, 1976, Siesjö 1977).


Citric Acid Cycle Succinic Semialdehyde Brain Energy Metabolism Metabolic Aspect Acta Physiol 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • B. K. Siesjö
    • 1
    • 2
  • C.-H. Nordström
    • 1
    • 2
  • S. Rehncrona
    • 1
    • 2
  1. 1.Brain Research Laboratory, E-BlocketUniversity HospitalLundSweden
  2. 2.Department of NeurosurgeryUniversity of LundLundSweden

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