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The Oxygen Sensing Characteristics of Microsomal Enzymes

  • Chapter
Tissue Hypoxia and Ischemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 78))

Abstract

The endoplasmic reticulum (microsomal fraction) of many types of tissues contains an electron transport system composed of hemoproteins and flavoproteins which function in the oxygen dependent transformation of a wide variety of natural and foreign chemicals. Although less well characterized than the mitochondrial respiratory chain, microsomal oxygenase reactions, in particular those in which cytochrome P-450 plays a central role, have attracted a great deal of attention recently because of the potential harmful effects of formed epoxide products as causative agents for chemical carcinogenesis as well as the function of this electron transport system for the detoxification of a variety of drugs as related to the pharmacologic effectiveness of these chemicals. The purpose of the present paper is to provide a brief overview of our current knowledge of the oxidative reactions catalyzed by microsomes and to identify a few areas of current interest related to the reaction of oxygen with the unique hemoprotein, cytochrome P-450. The details of many of these reactions have been discussed at recent symposia (1–4).

Supported in part bya grant (NIGMS - 16488) from the National Institutes of Health of the USPHS.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Texas Health Science Center, Dallas, Texas, 75235, USA

    Ronald W. Estabrook & Jurgen Werringloer

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  1. Ronald W. Estabrook
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  2. Jurgen Werringloer
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Editor information

Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, USA

    Martin Reivich , Ronald Coburn , Sukhamay Lahiri  & Britton Chance , ,  & 

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© 1977 Plenum Press, New York

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Estabrook, R.W., Werringloer, J. (1977). The Oxygen Sensing Characteristics of Microsomal Enzymes. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds) Tissue Hypoxia and Ischemia. Advances in Experimental Medicine and Biology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9035-4_2

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  • DOI: https://doi.org/10.1007/978-1-4615-9035-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9037-8

  • Online ISBN: 978-1-4615-9035-4

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