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The Oxygen Sensing Characteristics of Microsomal Enzymes

  • Ronald W. Estabrook
  • Jurgen Werringloer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)

Abstract

The endoplasmic reticulum (microsomal fraction) of many types of tissues contains an electron transport system composed of hemoproteins and flavoproteins which function in the oxygen dependent transformation of a wide variety of natural and foreign chemicals. Although less well characterized than the mitochondrial respiratory chain, microsomal oxygenase reactions, in particular those in which cytochrome P-450 plays a central role, have attracted a great deal of attention recently because of the potential harmful effects of formed epoxide products as causative agents for chemical carcinogenesis as well as the function of this electron transport system for the detoxification of a variety of drugs as related to the pharmacologic effectiveness of these chemicals. The purpose of the present paper is to provide a brief overview of our current knowledge of the oxidative reactions catalyzed by microsomes and to identify a few areas of current interest related to the reaction of oxygen with the unique hemoprotein, cytochrome P-450. The details of many of these reactions have been discussed at recent symposia (1–4).

Keywords

Liver Microsome Microsomal Enzyme Electron Transport System NADPH Oxidation Reduce Pyridine Nucleotide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Ronald W. Estabrook
    • 1
  • Jurgen Werringloer
    • 1
  1. 1.Department of BiochemistryUniversity of Texas Health Science CenterDallasUSA

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