Tissue PO2 in the Cat Carotid Body and Related Functions
The mechanism by which chemoreceptors sense changes in arterial oxygen and carbon dioxide remains a mystery (Biscoe1, Butler2, Howe3, Whalen4). In an effort to shed some light on this question we have measured tissue PO2 (TPO2) Polarographieally in the carotid body under a variety of conditions.
KeywordsCarotid Body Disappearance Curve Arterial Chemoreceptor Body Oxygen Consumption Oxygen Tension Measurement
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- 2.Butler, PJ, and Osborne, MP: A new theory for the receptor mechanism of the carotid body. J. Physiol. (London) 248: 22P–23P, 1975.Google Scholar
- 4.Whalen, WJ, Savoca, J, and Nair, P: Oxygen tension measurements in carotid body of the cat. Am. J. Physiol. 225: 986–991, 1967.Google Scholar
- 10.Eyzaguirre, C, and Lewin, J: Effect of different oxygen tensions on the carotid body in vitro. J. Physiol. (London) 159: 238–250, 1961.Google Scholar
- 12.Whalen, WJ, and Nair, P: “Hypoxic” discharge of chemoreceptors in the carotid body. Presented at Symposium: Tissue Responses to Anoxia and Ischemia. I.S.O.T.T. meetings, Anaheim, 1976.Google Scholar
- 13.Jobsis, FF: Basic processes in cellular respiration. In Fenn, WO, Rahn, H (Editors): Handbook of Physiology, Washington, D.C., American Physiological Society, 1964, vol. I., Sec. III, pp 111.Google Scholar
- 14.Whalen, WJ and Nair, P: Functional correlates with tissue PO2 in the carotid body. Presented at Oxygen Electrode Colloquium: Oxygen and Physiological Function. FASEB meetings, Anaheim, 1976.Google Scholar
- 15.Daly, MdeB, Lambertsen, CJ, and Schweitzer, A: Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat. J. Physiol. (London) 125: 67–89, 1954.Google Scholar
- 16.Purves, MJ: The effect of hypoxia, hypercapnia and hypotension upon carotid body blood flow and oxygen consumption in the cat. J. Physiol. (London) 209: 395–416, 1970.Google Scholar