Advertisement

Convergence of Stimuli in Arterial Chemoreceptors

  • R. W. Torrance
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)

Abstract

A single chemoreeeptor fibre of the carotid sinus nerve responds both to hypoxia and to hypercapnia/acidity of the arterial blood. These reactions have been well brought out by such recent studies as those of Lahiri1 which he has illustrated in a figure in his paper at this symposium. If reactions to CO2 are presented as a series of CO2 response curves at various intensities of hypoxia, the curves appear as a fan of approximately straight lines which have a steeper slope the more intense the hypoxia. It is when there is some degree of hypoxia that the effects of CO2 become marked in the steady state, as Neil2 has always emphasised, but if the PCO2 arterial blood is changing, the effects of CO2 on discharge are more striking, for adaptation of the response to a sudden change of PCO2 marked, particularly in hyperoxia. Thus if a receptor is discharging at some steady initial level and the PaCO2 is suddenly raised, the discharge immediately rises along a steep transient response curve and then adapts down to lie upon the steady state curve.

Keywords

Nerve Ending Carotid Body Pacinian Corpuscle Carotid Sinus Nerve Arterial Chemoreceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lahiri S, Delaney RG: Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibres. Respir.Physiol. 24: 249–266, 1975.PubMedCrossRefGoogle Scholar
  2. 2.
    Neil E: Panel discussion. In Hatcher JD, Jennings DB (Editors): Cardiovascular and Respiratory Effects of Hypoxia. Basel, Karger, 1966, p 171.Google Scholar
  3. 3.
    Travis DM: Molecular CO2 is inert on carotid chemoreceptor: demonstration by inhibition of carbonic anhydrase. J. Pharmacol. Exp. Ther. 178 : 529–540, 1971.PubMedGoogle Scholar
  4. 4.
    Biscoe TJ: Carotid Body: Structure and Function. Physiol.Rev. 51: 437–495, 1971.PubMedGoogle Scholar
  5. 5.
    Winder CV: On the mechanism of stimulation of carotid gland chemoreceptors. Am.J. Physiol. 118: 389–398, 1937.Google Scholar
  6. 6.
    Torrance RW: An amendment to Winder’s acid receptor hypothesis on the sensitivity of arterial chemoreceptors to hypoxia. J. Physiol. 244: 64–66P, 1975.Google Scholar
  7. 7.
    Pearse AGE, Polak JM, Rost FWD, Fontaine J, LeLievre C, LeDouarin N: Demonstration of the neural crest origin of Type I (APUD) cells in the avian carotid body, using a cytochemical marker system. Histochimie 34: 191–203, 1973.PubMedCrossRefGoogle Scholar
  8. 8.
    Barker JL, Smith TG: Peptide regulation of neuronal membrane properties. Brain Research 103: 167–170, 1976.PubMedCrossRefGoogle Scholar
  9. 9.
    Torrance RW: Arterial Chemoreceptors. In Widdicombe JG (Editor) Respiratory Physiology, International Review of Science Physiology, Series one Vol.2, pp 247–271, 1974.Google Scholar
  10. 10.
    Torrance RW: A New Version of the Acid Receptor Hypothesis of Carotid Chemoreceptors. In Paintal AS, (Editor): Morphology and Mechanisms of Chemoreceptors. Delhi, Vallabhbhai Patel Chest Institute 1976, pp 131–135.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. W. Torrance
    • 1
  1. 1.University Laboratory of PhysiologyOxfordEngland

Personalised recommendations