Bioassay and Pharmacologic Evaluation of the Adenosine Hypothesis

  • Francis J. Haddy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


Our approach to the mechanism of hypoxic, ischemic, and exercise dilation has differed from that of Berne and Rubio. We have mainly used bioassay and pharmacological techniques. The data generated by these techniques support the adenosine hypothesis1 for regulation of blood flow in cardiac and skeletal muscle and in addition suggest a contributory role for AMP in cardiac hypoxic dilation.


Adenosine Deaminase Reactive Hyperemia Gracilis Muscle Dilator Response Constrictor Response 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Francis J. Haddy
    • 1
  1. 1.Department of PhysiologyUniformed Services University of the Health SciencesBethesdaUSA

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