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Bioassay and Pharmacologic Evaluation of the Adenosine Hypothesis

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Tissue Hypoxia and Ischemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 78))

Abstract

Our approach to the mechanism of hypoxic, ischemic, and exercise dilation has differed from that of Berne and Rubio. We have mainly used bioassay and pharmacological techniques. The data generated by these techniques support the adenosine hypothesis1 for regulation of blood flow in cardiac and skeletal muscle and in addition suggest a contributory role for AMP in cardiac hypoxic dilation.

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References

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Authors and Affiliations

  1. Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20014, USA

    Francis J. Haddy

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  1. Francis J. Haddy
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Editor information

Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, USA

    Martin Reivich , Ronald Coburn , Sukhamay Lahiri  & Britton Chance , ,  & 

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© 1977 Plenum Press, New York

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Haddy, F.J. (1977). Bioassay and Pharmacologic Evaluation of the Adenosine Hypothesis. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds) Tissue Hypoxia and Ischemia. Advances in Experimental Medicine and Biology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9035-4_14

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  • DOI: https://doi.org/10.1007/978-1-4615-9035-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9037-8

  • Online ISBN: 978-1-4615-9035-4

  • eBook Packages: Springer Book Archive

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