The Sensing of Oxygen Tension in the Pulmonary Circulation — Discussion

  • Norman C. Staub
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


I think the reason I was invited to participate in this symposium was that I collaborated with Anton Hauge in some experiments suggesting histamine as the mediator by which reduced alveolar oxygen tension was sensed in the pulmonary circulation1. I am not going to defend histamine or any other mechanism, but will inquire as to how we can learn the truth about this fascinating problem that has led reputable scientists on a merry chase for decades. Dr. Fishman’s review2 covers all the essential issues. My brief comments will be confined to stating my approach to the problem, assembling the scattered results of our laboratory’s work which bear on the issue, and describing an interesting new lead. I will even mention histamine briefly.


Oxygen Tension Tissue Oxygen Tension Small Pulmonary Artery Alveolar Hypoxia Pulmonary Vascular Smooth Muscle 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Norman C. Staub
    • 1
  1. 1.Cardiovascular Research InstituteUniversity of CaliforniaSan Francisco, San FranciscoUSA

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