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The Sensing of Oxygen Tension in the Pulmonary Circulation

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Tissue Hypoxia and Ischemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 78))

Abstract

It now seems settled that acute hypoxia elicits pulmonary vasoconstriction and that the predominant site of constriction is the small muscular pulmonary artery1–3. What remains to be resolved is how this vasoconstriction comes about4.

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References

  1. Von Euler US, Liljestrand G: Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301–320, 1946.

    Article  Google Scholar 

  2. Fishman AP: Dynamics of the pulmonary circulation. In Hamilton WF, Dow P (Editors): Handbook of Physiology, Section 2, Circulation, vol 2. Washington, American Physiological Society, 1963, pp 1667–1743

    Google Scholar 

  3. Bergofsky EH: Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states. Am J Med 57:378–394, 1974.

    Article  PubMed  CAS  Google Scholar 

  4. Fishman AP: Hypoxia on the pulmonary circulation. Circ Res 38:221–231, 1976.

    Article  PubMed  CAS  Google Scholar 

  5. Szidon JP, Fishman AP: Autonomic control of the pulmonary circulation. In Fishman AP, Hecht HH (Editors): The Pulmonary Circulation and Interstitial Space. Chicago, University of Chicago Press, 1969, pp 239–268

    Google Scholar 

  6. Bergofsky EH, Holtzman S: A study of the mechanisms involved in the pulmonary arterial pressor response to hypoxia. Circ Res 20:506–519, 1967.

    Article  PubMed  CAS  Google Scholar 

  7. Torrance RW: The idea of a chemoreceptor. In Fishman AP, Hecht HH (Editors): The Pulmonary Circulation and Interstitial Space. Chicago, University of Chicago Press, 1969, pp 223–237

    Google Scholar 

  8. Somlyo AP, Somlyo AV: Vascular smooth muscle. II. Pharmacology of normal and hypertensive vessels. Pharmacol Rev 22:249–353, 1970.

    PubMed  CAS  Google Scholar 

  9. Detar R, Bohr DF: Oxygen and vascular smooth muscle contraction. Am J Physiol 214:241–244, 1968.

    PubMed  CAS  Google Scholar 

  10. Detar R, Bohr DF: Contractile responses of isolated vascular smooth muscle during prolonged exposure to anoxia. Am J Physiol 222:1269–1277, 1972.

    PubMed  CAS  Google Scholar 

  11. Kay JM, Grover RF: Lung mast cells and hypoxic pulmonary hypertension. Prog Respir Res 9:157–164, 1975.

    Google Scholar 

  12. Lloyd TC Jr: Role of nerve pathways in the hypoxic vasoconstriction of lung. J Appl Physiol 21:1351–1355, 1966.

    PubMed  Google Scholar 

  13. Hauge A: Conditions governing the pressor response to ventilation hypoxia in isolated perfused rat lungs. Acta Physiol Scand 72:33–44, 1968.

    Article  PubMed  CAS  Google Scholar 

  14. Daly I de B, Michel CC, Ramsay DJ, Waaler BA: Conditions governing the pulmonary vascular response to ventilation hypoxia and hypoxaemia in the dog. J Physiol (Lond) 196:351–379, 1968.

    CAS  Google Scholar 

  15. Hauge A: Hypoxia and pulmonary vascular resistance: the relative effects of pulmonary arterial and alveolar PO2. Acta Physiol Scand 76:121–130, 1969.

    Article  PubMed  CAS  Google Scholar 

  16. Hauge A, Staub NC: Prevention of hypoxic vasoconstriction in cat lung by histamine-releasing agent 48/80. J Appl Physiol 26:693–699, 1969.

    PubMed  CAS  Google Scholar 

  17. Silove ED, Simcha AJ: Histamine-induced pulmonary vasodilatation in the calf; relationship to hypoxia. J Appl Physiol 35:830–836, 1973.

    PubMed  CAS  Google Scholar 

  18. Said SI, Voshida T, Kitamura S, Vreim G: Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators. Science 185:1181–1183, 1974.

    Article  PubMed  CAS  Google Scholar 

  19. Vaage J, Hauge A: Prostaglandins and the pulmonary vasoconstrictor response to alveolar hypoxia. Science 189:899–900, 1975.

    Article  PubMed  CAS  Google Scholar 

  20. Harvey RM, Enson Y, Betti R, Lewis ML, Rochester DF, Ferrer MI: Further observations on the effect of hydrogen ion on the pulmonary circulation. Circulation 35:1019–1027, 1967.

    Article  PubMed  CAS  Google Scholar 

  21. Barer GW, McCurrie JR: Pulmonary vasomotor responses in the cat: the effect and interrelationship of drugs, hypoxia and hypercapnia. Q J Exp Physiol 54:156–172, 1969.

    CAS  Google Scholar 

  22. McMurtry IF, Reeves JT, Grover RF: Inhibition by verapamil of pulmonary vasoconstrictive response to alveolar hypoxia. Physiologist 17:285, 1974.

    Google Scholar 

  23. Souhrada JF, Dickey DW: Effect of substrate on hypoxic response of pulmonary artery. J Appl Physiol 40:533–538, 1976.

    PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Fishman, A.P. (1977). The Sensing of Oxygen Tension in the Pulmonary Circulation. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds) Tissue Hypoxia and Ischemia. Advances in Experimental Medicine and Biology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9035-4_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9035-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9037-8

  • Online ISBN: 978-1-4615-9035-4

  • eBook Packages: Springer Book Archive

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