Advertisement

Prostaglandins and the Control of Muscle Tone in the Ductus Arteriosus

  • F. Coceani
  • P. M. Olley
  • I. Bishai
  • E. Bodach
  • J. Heaton
  • M. Nashat
  • E. White
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)

Abstract

For many years it was assumed that the patency of the ductus arteriosus in the foetus is a passive state determined by the haemodynamic balance of the pulmonary and systemic circulations rather than by the action of the smooth muscle in the vessel wall (for a review, see ref. 1). As a result, research focussed upon the events occurring during the immediate postnatal period when the vessel constricts in response to the physiological elevation in blood oxygen tension. The mechanism of the contractile action of oxygen has been the subject of extensive investigation. Several authors (see ref. 1) speculated that oxygen does not act on smooth muscle directly but through the formation of, or the sensitization to, a vasoactive agent. Many different compounds — i.e., acetylcholine, norepinephrine, histamine, bradykinin — were studied, but none of them turned out to be suited to this role (2 – 4). The work of Fay (this volume) represents an original approach to this problem and his findings, while not excluding the occurrence in the tissue of a constrictor agent functionally linked to oxygen, prove that oxygen action is exerted upon cytochrome-dependent oxidative processes.

Keywords

Smooth Muscle Tone Functional Closure Blood Oxygen Tension Physiological Elevation Foetal Ductus Arteriosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Heymann MA., Rudolph AM: Control of the ductus arteriosus. Physiol Rev 55:62–78, 1975.PubMedGoogle Scholar
  2. 2.
    Kovalčik V: The response of the isolated ductus arteriosus to oxygen and anoxia. J Physiol (Lond) 169:185–197, 1963.Google Scholar
  3. 3.
    Knight DH, Patterson DF, Melbin J: Constriction of the fetal ductus arteriosus induced by oxygen, acetylcholine and norepinephrine in normal dogs and those genetically predisposed to persistent patency. Circulation 17:127–132, 1973.CrossRefGoogle Scholar
  4. 4.
    Perin E, Coceani F, Olley PM: Another look at the role of acetylcholine (ACh) in the closure of the ductus arteriosus. Proc Can Fed Biol Soc 17:120, 1974.Google Scholar
  5. 5.
    Coceani F, Olley FM: The response of the ductus arteriosus to prostaglandins. Can J Physiol Pharmacol 51:220–225, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Starling MB, Elliott RB: The effects of prostaglandins, prostaglandin inhibitors, and oxygen on the closure of the ductus arteriosus, pulmonary arteries and umbilical vessels in vitro. Prostaglandins 8:187–203, 1974.PubMedCrossRefGoogle Scholar
  7. 7.
    Coceani F, Olley PM, Bodach E: Prostaglandins: a possible regulator of muscle tone in the ductus arteriosus. In Samuelsson B, Paoletti R (Editors): Advances in Prostaglandin and Thromboxane Research. New York, Raven Press, 1976, vol 1, pp 417–424.Google Scholar
  8. 8.
    Coceani F, Olley PM, Bodach E: Lamb ductus arteriosus: effect of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandin E2. Prostaglandins 9:299–308, 1975.PubMedCrossRefGoogle Scholar
  9. 9.
    Olley PM, Bodach E, Heaton J, Coceani F: Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus. Eur J Pharmacol 34:247–250, 1975.PubMedCrossRefGoogle Scholar
  10. 10.
    van Dorp DA: Aspects of the biosynthesis of prostaglandins. Progr biochem Pharmacol 3:71–82, 1967.Google Scholar
  11. 11.
    Nugteren DH, van Dorp DA: The participation of molecular oxygen in the biosynthesis of prostaglandins. Biochim Biophys Acta 98:654–656, 1965.PubMedCrossRefGoogle Scholar
  12. 12.
    Samuelsson B: On the incorporation of oxygen in the conversion of 8,11,14-eicosatrienoic acid to prostaglandin E. J Am Chem Soc 87:3011–3013, 1965.PubMedCrossRefGoogle Scholar
  13. 13.
    Coc eani F, Pace-Asciak C, Volta F, Wolfe LS: Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Am J Physiol 213:1056–1064, 1967.PubMedGoogle Scholar
  14. 14.
    Olley PM, White EP, Bodach E, Heaton J, Coceani F: The contractile response of the developing lamb ductus arteriosus to ibuprofen. 49th Meeting Am Heart Ass (Miami) November 1976.Google Scholar
  15. 15.
    Sharpe GL, Thalme B, Larsson KS: Studies on closure of the ductus arteriosus. XI. Ductal closure in uteroby a prostaglandin synthetase inhibitor. Prostaglandins 8:363–368, 1974.PubMedCrossRefGoogle Scholar
  16. 16.
    Sharpe GL, Larsson KS, Thalme B: Studies on the closure of the ductus arteriosus. XII. In uteroeffect of indomethacin and sodium salicylate in rats and rabbits. Prostaglandins 9: 585–596, 1975.PubMedCrossRefGoogle Scholar
  17. 17.
    Heymann MA, Rudolph AM: Effects of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Circulation Res 38:418–422, 1976.PubMedCrossRefGoogle Scholar
  18. 18.
    Friedman WF, Hirschklau MJ, Pitlick PT, Kirkpatrick SE: Pharmacological closure of patent ductus in the premature. Pediat Res 10:312, 1976.Google Scholar
  19. 19.
    Elliott RB, Starling MB, Neutze JM: Medical manipulation of the ductus arteriosus. Lancet 1:140–142, 1975.PubMedCrossRefGoogle Scholar
  20. 20.
    Coceani F, Wolfe LS: On the action of prostaglandin E1and prostaglandins from brain on the isolated rat stomach. Can J Physiol Pharmacol 44:933–950, 1966.PubMedCrossRefGoogle Scholar
  21. 21.
    Paton DM, Daniel EE: On the contractile response of the isolated rat uterus to prostaglandin E1. Can J Physiol Pharmacol 45:795–804, 1967.PubMedCrossRefGoogle Scholar
  22. 22.
    Eckenfels A, Vane JR: Prostaglandins, oxygen tension and smooth muscle tone. Br J Pharmacol 45:451–462, 1972.PubMedCrossRefGoogle Scholar
  23. 23.
    Chandler JT, Strong CG: The actions of prostaglandin E1on isolated rabbit aorta. Arch int Pharmacodyn 197:123–131, 1972.PubMedGoogle Scholar
  24. 24.
    Splawinski JA, Nies AS, Sweetman B, Oates JA: The effects of arachidonic acid, prostaglandin E2and prostaglandin F2aon the longitudinal stomach strip of the rat. J Pharmacol Exp Ther 187:501–510, 1973.PubMedGoogle Scholar
  25. 25.
    Wilson WR, Greenberg S, Kadowitz PJ, Diecke FPJ, Long JP: Interaction of prostaglandin A2and prostaglandin B2on vascular smooth muscle tone, vascular reactivity and electrolyte transport. J Pharmacol Exp Ther 195:565–576, 1975.Google Scholar
  26. 26.
    Kirkland SJ, Baum H: Prostaglandin E1may act as a “calcium ionophore”. Nature 236:47–49, 1972.CrossRefGoogle Scholar
  27. 27.
    Carafoli E, Crovetti F: Interactions between prostaglandin E1and calcium at the level of the mitochondrial membrane. Arch Biochem Biophys 154:40–46, 1973.PubMedCrossRefGoogle Scholar
  28. 28.
    Elliott RB, Starling MB: The effects of prostaglandin F2ain the closure of the ductus arteriosus. Prostaglandins 2: 399–403, 1972.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • F. Coceani
    • 1
  • P. M. Olley
    • 1
  • I. Bishai
    • 1
  • E. Bodach
    • 1
  • J. Heaton
    • 1
  • M. Nashat
    • 1
  • E. White
    • 1
  1. 1.Research InstituteThe Hospital For Sick ChildrenTorontoCanada

Personalised recommendations