What is a Molecular Oxygen Sensor? What is a Transduction Process?

  • Frans F. Jobsis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 78)


The task set for me by the organizing committee is simultaneously difficult, simple and intimidating. Difficult because of the need to look for order in a nebulous meeting ground of physiology and biochemistry. Simple because of a relative lack of solid information. And intimidating because of the importance of the topic and this audience of distinguished investigators of the topic assembled here before me.


Gastric Mucosa Respiratory Chain Acid Secretion Carotid Body Reduction Level 
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    Hersey, S.J. and Jobsis, F.F.: Redox changes in the respiratory chain related to acid secretion by the intact gastric mucosa. Biochem. Biophys. Res. Comm. 36:243–250, 1969.PubMedCrossRefGoogle Scholar
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    Hersey, S.J. and High, W.L.: Effect of unstirred layers on oxygenation of frog gastric mucosa. Am. J. Physiol., 223:903–909, 1972.PubMedGoogle Scholar
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    Hempel, F.G., Jobsis, F.F., LaManna, J.C., Rosenthal, M. and Saltzman, H.A.: Oxidation of cerebral cytochrome a,a 3 by oxygen plus carbon dioxide at hyperbaric pressures. Submitted to J. Appl. Physiol.Google Scholar
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    Rosenthal, M. and LaManna, J.C.: Oxidative metabolism and electrophysiological activity in the intact central nervous system. In: Oxygen and Physiological Function. F.F. Jobsis, Ed. Professional Information Library, Dallas, 1976.Google Scholar
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    Moffett, D. and Jobsis, F.F.: Response of toad brain respiratory chain enzymes to ouabain, elevated potassium and electrical stimulus. Brain Re. In press, 1976.Google Scholar
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    Rosenthal, M., LaManna, J.C., Jobsis, F.F., Levasseur, J.E., Kontos, H.A. and Patterson, J.L.: Effects of respiratory gases on cytochrome a in intact cerebral cortex. Is there a critical PO2? Brain Res., 108:143–154, 1976.PubMedCrossRefGoogle Scholar
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    Mills, E. and Jobsis, F.F.: Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J. Neurophysiol., 35:405–428, 1972.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Frans F. Jobsis
    • 1
  1. 1.Department of Physiology and PharmacologyDuke UniversityDurhamUSA

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