Abstract
Lethal recessive mutations should be expressed in diploid cells with a frequency equal to the square of that in haploid cells. According to mutation rates in bacteria, therefore, the proportion of diploid cells which survive mutagen treatment should be at least 105 times that of haploid cells. A haploid-diploid comparison should, in fact, be a test for the mutagenic nature of a compound.
Chapter PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Mezger-Freed, L. (1975). The Survival of Haploid and Diploid Vertebrate Cells after Treatment with Mutagens. In: Cristofalo, V.J., Roberts, J., Adelman, R.C. (eds) Explorations in Aging. Advances in Experimental Medicine and Biology, vol 61. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9032-3_19
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9032-3_19
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4615-9034-7
Online ISBN: 978-1-4615-9032-3
eBook Packages: Springer Book Archive