Abstract
Aspects of DNA metabolism in aged human fibroblasts and fibroblasts from patients with the Hutchinson-Gilford progeria syndrome have been compared to aneuploid and hybrid mammalian cells. We find the dynamics of DNA metabolism as measured by rejoining of radiation-induced DNA breaks and cyclic repair of DNA is decreased in the “old” cells and in certain progeric cells. Aged fibroblasts and strains of progeric fibroblasts EX-441 and AK are more susceptible to cell death as measured by endonucleolytic DNA degradation.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Williams, J.R., Little, J.B., Epstein, J., Brown, W. (1975). Altered DNA Metabolism in Aged and Progeric Fibroblasts. In: Cristofalo, V.J., Roberts, J., Adelman, R.C. (eds) Explorations in Aging. Advances in Experimental Medicine and Biology, vol 61. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9032-3_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9032-3_18
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4615-9034-7
Online ISBN: 978-1-4615-9032-3
eBook Packages: Springer Book Archive